Potential Cardio-protective Role of Dapagliflozin in Post Myocardial Infarction Patients
rafla, M., Abdelraheem, M., Hareedy, M., ELSAUGHIER, S. (2023). Potential Cardio-protective Role of Dapagliflozin in Post Myocardial Infarction Patients. EKB Journal Management System, 3(2), 147-156. doi: 10.21608/aumj.2023.230195.1063
mariam melad rafla; Mahmoud Hamdy Abdelraheem; Mohammad Salem Hareedy; SAUD MOHAMED ELSAUGHIER. "Potential Cardio-protective Role of Dapagliflozin in Post Myocardial Infarction Patients". EKB Journal Management System, 3, 2, 2023, 147-156. doi: 10.21608/aumj.2023.230195.1063
rafla, M., Abdelraheem, M., Hareedy, M., ELSAUGHIER, S. (2023). 'Potential Cardio-protective Role of Dapagliflozin in Post Myocardial Infarction Patients', EKB Journal Management System, 3(2), pp. 147-156. doi: 10.21608/aumj.2023.230195.1063
rafla, M., Abdelraheem, M., Hareedy, M., ELSAUGHIER, S. Potential Cardio-protective Role of Dapagliflozin in Post Myocardial Infarction Patients. EKB Journal Management System, 2023; 3(2): 147-156. doi: 10.21608/aumj.2023.230195.1063

Potential Cardio-protective Role of Dapagliflozin in Post Myocardial Infarction Patients

Aswan University Medical Journal
Volume 3, Issue 2, December 2023, Page 147-156  XML PDF (992.14 K)
Document Type: Original Article
DOI: 10.21608/aumj.2023.230195.1063
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Authors
mariam melad rafla email 1; Mahmoud Hamdy Abdelraheem2; Mohammad Salem Hareedy3; SAUD MOHAMED ELSAUGHIER4
1medical pharmacology/ Faculty of medicine/Aswan university
2medical pharmacology at faculty of medicine Assiut university
3medical pharmacology/faculty of medicine/assiut university
4cardiology department/Aswan hospital/Aswan university
Abstract
Background:
Type II diabetes mellitus and ischemic heart disease (IHD) commonly coexist and can be dangerous. The sodium glucose cotransporter-II inhibitors (SGLT2i) are a new class of diabetes treatment that reduces IHD hospitalization and cardiovascular (CV) mortality. (SGLT2i) obviously results in a significant decrease in IHD risk; however, the mechanism of these effects is not clear. This study aimed to evaluate the possible treatment effect of dapagliflozin on diabetic patients with anterior (STEMI) treated by primary percutaneous coronary intervention (PCI).
Methods:
A randomized control trial enrolled 60 type II diabetic patients with anterior (STEMI) treated by primary (PCI) from both genders and their ages above 18 years old. The patients were categorized to two groups, Group (A) included 30 patients did not take dapagliflozin but they took the ordinary anti-ischemic & anti heart failure drugs also anti-diabetic medications. Group (B) enrolled 30 patients received dapagliflozin and they treated by ordinary anti-ischemic, anti-heart failure drug therapy and anti-diabetic medications.
Results:
In group (B) treated by dapagliflozin there was statistically highly significant improvement in LV systolic function by GLS, LVEF and LVEDD and LVESD in comparison with group (A) (P value<0.0001).
Conclusion:
Dapagliflozin played a substantial role in cardiac remodeling, including decrease the LVEDD, LVSD as well as improvement in left ventricular systolic function.
Keywords
STEMI; GLS; PCI; Dapagliflozin
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