Cymbopogon Citratus Alleviates Mancozeb- mediated Renal Toxicity in a Rat Model Through Combating Inflammation, Oxidative Stress, and Apoptosis.
Mesallam, D., Elkhishin, I., abdelkader, S., Abdelwahab, M., Abd El-Fatah, S., Atef, M. (2023). Cymbopogon Citratus Alleviates Mancozeb- mediated Renal Toxicity in a Rat Model Through Combating Inflammation, Oxidative Stress, and Apoptosis.. EKB Journal Management System, 11(2), 63-78. doi: 10.21608/esctj.2023.242827.1043
Dalia Ibrahim Ahmed Mesallam; Iman Abdel-Rady Elkhishin; Shymaa Mohamed abdelkader; Mai Abdelwahab; Samaa Salah Abd El-Fatah; Mona Atef. "Cymbopogon Citratus Alleviates Mancozeb- mediated Renal Toxicity in a Rat Model Through Combating Inflammation, Oxidative Stress, and Apoptosis.". EKB Journal Management System, 11, 2, 2023, 63-78. doi: 10.21608/esctj.2023.242827.1043
Mesallam, D., Elkhishin, I., abdelkader, S., Abdelwahab, M., Abd El-Fatah, S., Atef, M. (2023). 'Cymbopogon Citratus Alleviates Mancozeb- mediated Renal Toxicity in a Rat Model Through Combating Inflammation, Oxidative Stress, and Apoptosis.', EKB Journal Management System, 11(2), pp. 63-78. doi: 10.21608/esctj.2023.242827.1043
Mesallam, D., Elkhishin, I., abdelkader, S., Abdelwahab, M., Abd El-Fatah, S., Atef, M. Cymbopogon Citratus Alleviates Mancozeb- mediated Renal Toxicity in a Rat Model Through Combating Inflammation, Oxidative Stress, and Apoptosis.. EKB Journal Management System, 2023; 11(2): 63-78. doi: 10.21608/esctj.2023.242827.1043

Cymbopogon Citratus Alleviates Mancozeb- mediated Renal Toxicity in a Rat Model Through Combating Inflammation, Oxidative Stress, and Apoptosis.

Egyptian Society of Clinical Toxicology Journal
Volume 11, Issue 2, December 2023, Page 63-78  XML PDF (2.25 MB)
Document Type: Original Article
DOI: 10.21608/esctj.2023.242827.1043
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Authors
Dalia Ibrahim Ahmed Mesallam email 1; Iman Abdel-Rady Elkhishin2; Shymaa Mohamed abdelkader3; Mai Abdelwahab4; Samaa Salah Abd El-Fatah5; Mona Atef6
1Forensic Medicine and Clinical Toxicology Department,Faculty of Medicine, Zagazig University, Egypt
2Forensic medicine and clinical toxicology department, Faculty of Medicine, Zagazig University, Zagazig, Egypt
3Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt
4Pathology department, Faculty of Medicine, Zagazig University, Zagazig, Egypt
5Human anatomy and embryology department, Faculty of Medicine, Zagazig University, Zagazig, Egypt
6forensic medicine and clinical toxicology department, Faculty of Medicine, Zagazig University, Zagazig, Egypt
Abstract
Background: One of the most widely used dithiocarbamate fungicides around the world is Mancozeb (MZ). It is used in domestic, agricultural, and industrial applications which can increase its toxic effects. Lemongrass essential oil (LGEO) offers a broad scope of health benefits. This experiment aimed to investigate LGEO role in reducing renal toxicity induced by MZ in rats. Material and Methods: Seventy-five adult male albino rats were equally and randomly allotted into five groups (15 rats/group): The control groups (negative and vehicle), the Lemongrass group received LGEO 200 mg/kg, the MZ-treated group received 750 mg/kg MZ, and the combined group received LGEO with MZ as same doses mentioned before. The animals were treated orally for 8 weeks. Results: MZ Administration revealed a significant rise in serum creatinine, blood urea, and renal tissue malondialdehyde (MDA) levels, while superoxide dismutase (SOD) activities and glutathione content levels were significantly reduced in comparison to the control group. Also, the treated group with MZ revealed increased DNA damage and altered kidney histopathology, increased collagen deposit, with high expression of TNF-α, 8-OHdG, and p53 in renal tissue, as well as a high score of congestion, haemorrhage, infiltration, and necrosis. The rats treated with LGEO and MZ demonstrated partial improvement based on comet assay, renal oxidative stress parameters, and histopathological and immunohistochemical investigations. Conclusion: LGEO administration attenuates MZ induced renal injury via modulation of their oxidant, inflammatory, and apoptotic impacts. Recommendation: encourage use of safety measures as well as LGEO consumption among farmers to reduce MZ health consequences.
Keywords
Mancozeb; dithiocarbamate; Lemongrass essential oil; GC-MS
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