Acidified QuEChERS method followed by GC-MS/MS on-cold injection for the determination of captan and folpet metabolites in strawberries and apple
Hamzawy, A., Elsebaey, M., Prodhan, M. (2023). Acidified QuEChERS method followed by GC-MS/MS on-cold injection for the determination of captan and folpet metabolites in strawberries and apple. EKB Journal Management System, 61(3), 55-63. doi: 10.21608/ejaps.2023.240353.1074
Ahmed H. Hamzawy; Mohammed Elsebaey; Mohammad Dalower Hossain Prodhan. "Acidified QuEChERS method followed by GC-MS/MS on-cold injection for the determination of captan and folpet metabolites in strawberries and apple". EKB Journal Management System, 61, 3, 2023, 55-63. doi: 10.21608/ejaps.2023.240353.1074
Hamzawy, A., Elsebaey, M., Prodhan, M. (2023). 'Acidified QuEChERS method followed by GC-MS/MS on-cold injection for the determination of captan and folpet metabolites in strawberries and apple', EKB Journal Management System, 61(3), pp. 55-63. doi: 10.21608/ejaps.2023.240353.1074
Hamzawy, A., Elsebaey, M., Prodhan, M. Acidified QuEChERS method followed by GC-MS/MS on-cold injection for the determination of captan and folpet metabolites in strawberries and apple. EKB Journal Management System, 2023; 61(3): 55-63. doi: 10.21608/ejaps.2023.240353.1074

Acidified QuEChERS method followed by GC-MS/MS on-cold injection for the determination of captan and folpet metabolites in strawberries and apple

Egyptian Journal of Pure and Applied Science
Volume 61, Issue 3, October 2023, Page 55-63  XML PDF (1.5 MB)
Document Type: Original Article
DOI: 10.21608/ejaps.2023.240353.1074
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Authors
Ahmed H. Hamzawy email orcid 1; Mohammed Elsebaey1; Mohammad Dalower Hossain Prodhanorcid 2
1Agricultural Research Center, Central Laboratory of Residue Analysis of Pesticides and Heavy Metals in Foods (QCAP), P.O. Box: 12311, Dokki, Giza, Egypt
2Pesticide Research & Environmental Toxicology Section, Entomology Division, Bangladesh Agricultural Research Institute (BARI), Gazipur-1701, Bangladesh
Abstract
In this work, the on-cold injection GC-MS/MS approach's development and evaluation for the simultaneous determination of both captan and folpet metabolites with endpoint backflush had been evaluated. An acidified QuEChERS approach for sample extraction, accompanied by the on-cold GC-MS/MS approach, provides an accurate quantification of captan and folpet metabolites in apple and strawberries at reporting limit (LOQ= 10µg/kg), which was lower than the EU-MRL and NAFSA-MRL. The method shows the analytical matrix effect, which was higher in apples (134%, 152%) than strawberries (83%, 115%) for captan and folpet metabolites tetrahydro phthalimide (THPI) and phthalimide (PI), consecutively. However, apple and strawberries correlation characteristics at three spiking levels of 10, 50, and 100µg/kg of both captan and folpet indicated a linear relationship (R2>0.99) which proves the reduction of the matrix effect. The recovery of captan metabolite ranged from 97% to122% and 80% to107%, while folpet metabolite ranged from 77% to104% and 78% to 111% for apple and strawberries, respectively, with RSD pooled <10%. The result confirms both method robustness and fits for their intended use that permits the practice in routine analysis.
Keywords
THPI; PHI; GC-MS/MS; QuEChERS; Apple
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