Facile Synthesis and Structural Characterization of Some Phthalazin-1(2H)-one Derivatives as Antimicrobial Nucleosides and Reactive Dye
EL-Hashash, M., Rizk, S., El-Bassiouny, F., Guirguis, D., Khairy, S., Guirguis, L. (2017). Facile Synthesis and Structural Characterization of Some Phthalazin-1(2H)-one Derivatives as Antimicrobial Nucleosides and Reactive Dye. EKB Journal Management System, 60(3), 407-420. doi: 10.21608/ejchem.2017.915.1043
Maher EL-Hashash; Sameh Rizk; Fakhri El-Bassiouny; Dalal Guirguis; Sherif Khairy; Laila Guirguis. "Facile Synthesis and Structural Characterization of Some Phthalazin-1(2H)-one Derivatives as Antimicrobial Nucleosides and Reactive Dye". EKB Journal Management System, 60, 3, 2017, 407-420. doi: 10.21608/ejchem.2017.915.1043
EL-Hashash, M., Rizk, S., El-Bassiouny, F., Guirguis, D., Khairy, S., Guirguis, L. (2017). 'Facile Synthesis and Structural Characterization of Some Phthalazin-1(2H)-one Derivatives as Antimicrobial Nucleosides and Reactive Dye', EKB Journal Management System, 60(3), pp. 407-420. doi: 10.21608/ejchem.2017.915.1043
EL-Hashash, M., Rizk, S., El-Bassiouny, F., Guirguis, D., Khairy, S., Guirguis, L. Facile Synthesis and Structural Characterization of Some Phthalazin-1(2H)-one Derivatives as Antimicrobial Nucleosides and Reactive Dye. EKB Journal Management System, 2017; 60(3): 407-420. doi: 10.21608/ejchem.2017.915.1043

Facile Synthesis and Structural Characterization of Some Phthalazin-1(2H)-one Derivatives as Antimicrobial Nucleosides and Reactive Dye

Egyptian Journal of Chemistry
Article 5, Volume 60, Issue 3, June 2017, Page 407-420  XML PDF (1.32 MB)
DOI: 10.21608/ejchem.2017.915.1043
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Authors
Maher EL-Hashash1; Sameh Rizkorcid 1; Fakhri El-Bassiouny1; Dalal Guirguis1; Sherif Khairy email 2; Laila Guirguis2
1Department of Organic Chemistry, Faculty of Science, University of Ain Shams
2Department Of Reactor Materials , Nuclear Material Authority, Cairo, Egypt.
Abstract
Abstract: A new series of 2,4-disubstituted phthalazin-1(2H)-one derivatives was synthesized via nucleophilic attach of N-2 of phthalazin-1(2H)-one derivatives on different monosuccharides. Synthesis of phthalazinone nucleosides were very effective as antimicrobial. Also the phthalazinone moiety can be used in synthesis of reactive nucleosides and dyes that was chemically bonded with proteins and fibers respectively as afforded highly stability of dyestuff wool and cotton textiles. The structure of the prepared compounds was elucidated by physical and spectral data like FT-IR, 1H- and 13C-NMR.
Keywords
Keywords: phthalazin-1(2H)one; allyl-; propargyl-phthalazinone; epchlorohydrin; Nucleosides; Reactive dye
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