AMELIORATIVE EFFECT OF COPPER ALBUMIN COMPLEX AGAINST AFLATOXICOSIS COMPARED WITH CURCUMIN | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Article 14, Volume 47, Issue 1, June 2024, Page 217-231 PDF (1.59 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.2023.242393.1947 | ||||
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| Authors | ||||
Aisha A. El-Waheed1; Ahmed R. Shatat 1; Gamal A. Gouda  2
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| 1Department of Chemistry, Faculty of Science, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt | ||||
| 2Department of Chemistry, Faculty of Science, Al-Azhar University, Assiut 71524, Egypt | ||||
| Abstract | ||||
| Abstract In order to assess the potential protective effects of curcumin and the copper albumin complex on aflatoxin B1 (AFB1) toxicity in animal rats, 60 male albino rats were separated into the following four groups: Group 1 serves as the control, Group 2 administers AFB1 orally just three times at a weak dose for five weeks, Group 3 administers the same dose of AFB1 and curcumin (200 mg/kg B.W. diluted in 25 ml maize oil), and Group 4 administers the same dose of AFB1 and the copper albumin complex (0.8 g m/kg B.W.) orally. Following the completion of the experiment, the animals were scarified, blood and tissue samples were taken for biochemical and histological analysis. The findings of this study demonstrated that copper albumin complex had superior protective effects against Aflatoxicosis compared to curcumin. This may be because copper albumin complex has antioxidant properties. According to the findings of this study, the toxicological effects of AFB1 can be avoided by adding copper albumin complex as a food additive. | ||||
| Keywords | ||||
| Keywords: Aflatoxicosis; copper (I) albumin complex; curcumin | ||||
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