Prevalence of Helicobacter Pylori Infection among Egyptian patients with hypothyroidism and its relation to treatment resistance in Beni-Suef Governorate
Mohamed, M., Mohamed, E., Shaker, M., Othman, M. (2024). Prevalence of Helicobacter Pylori Infection among Egyptian patients with hypothyroidism and its relation to treatment resistance in Beni-Suef Governorate. EKB Journal Management System, 5(1), 178-184. doi: 10.21608/mid.2023.249166.1664
Mohamed Gamal Mohamed; Eman Hamdy Mohamed; Marwa Abdallah Shaker; Mona Kamal Othman. "Prevalence of Helicobacter Pylori Infection among Egyptian patients with hypothyroidism and its relation to treatment resistance in Beni-Suef Governorate". EKB Journal Management System, 5, 1, 2024, 178-184. doi: 10.21608/mid.2023.249166.1664
Mohamed, M., Mohamed, E., Shaker, M., Othman, M. (2024). 'Prevalence of Helicobacter Pylori Infection among Egyptian patients with hypothyroidism and its relation to treatment resistance in Beni-Suef Governorate', EKB Journal Management System, 5(1), pp. 178-184. doi: 10.21608/mid.2023.249166.1664
Mohamed, M., Mohamed, E., Shaker, M., Othman, M. Prevalence of Helicobacter Pylori Infection among Egyptian patients with hypothyroidism and its relation to treatment resistance in Beni-Suef Governorate. EKB Journal Management System, 2024; 5(1): 178-184. doi: 10.21608/mid.2023.249166.1664

Prevalence of Helicobacter Pylori Infection among Egyptian patients with hypothyroidism and its relation to treatment resistance in Beni-Suef Governorate

Microbes and Infectious Diseases
Article 19, Volume 5, Issue 1, February 2024, Page 178-184  XML PDF (744.26 K)
Document Type: Original Article
DOI: 10.21608/mid.2023.249166.1664
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Authors
Mohamed Gamal Mohamed email orcid 1; Eman Hamdy Mohamed2; Marwa Abdallah Shaker3; Mona Kamal Othman1
1Internal medicine department, Faculty of medicine, Beni-Suef University, Beni-Suef, Egypt
2Clinical and chemical pathology department, Faculty of medicine, Beni-Suef University, Beni-Suef, Egypt
3Tropical medicine department, Faculty of medicine, Beni-Suef University, Beni-Suef, Egypt
Abstract
Background and rationale: Hypothyroidism is a common condition of thyroid hormone deficiency, which is readily diagnosed and managed but potentially fatal in severe cases if untreated. Helicobacter pylori (H. pylori) infection has been associated with an increased risk of thyroid diseases (TDs) and it may cause some sort of mal absorption to thyroxine replacement therapy causing a treatment refractory state. Aim of work: The aim of the work is to estimate the prevalence of H. pylori in hypothyroid patients and its relation to unresponsiveness to treatment. Patients and method: We analyzed 211 hypothyroid patient on treatment. We estimate stool antigen for H. pylori and correlate it with other parameters in hypothyroid patients. Results:  Two hundred and eleven (211) patients were included in this study, of these, 101/211 (47.9%) were euthyroid on treatment and 110/211 (52.1%) had refractory hypothyroidism with high dose of LT4. The mean age of patients in our study was 55.67 ± 13.53 years, with 151 (71.6%) female patients.  In the current study, we noticed that prevalence of H. pylori was higher in treatment refractory hypothyroidism than euthyroid patients. Conclusions: This study suggested that there is a significant association between H. pylori infection and treatment-refractory hypothyroidism. And eradication of H. pylori may help in overcoming the issue of resistant to thyroxine therapy.
Keywords
H pylori; refractory hypothyroidism; stool antigen; thyroxine
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