PREDICTION OF EARLY ANASTOMOTIC LEAKAGE FOLLOWING COLORECTAL CANCER SURGERY IN ZAGAZIG UNIVERSITY HOSPITALS
Anwar, P., Abd El-Rahman, M., Baiomy, T., Ashour, H. (2020). PREDICTION OF EARLY ANASTOMOTIC LEAKAGE FOLLOWING COLORECTAL CANCER SURGERY IN ZAGAZIG UNIVERSITY HOSPITALS. EKB Journal Management System, 26(2), 204-214. doi: 10.21608/zumj.2019.11299.1175
Pola Nagy Anwar; Mohammed Said Abd El-Rahman; Taha Abd El-Wahab Baiomy; Hassan Rabea Ashour. "PREDICTION OF EARLY ANASTOMOTIC LEAKAGE FOLLOWING COLORECTAL CANCER SURGERY IN ZAGAZIG UNIVERSITY HOSPITALS". EKB Journal Management System, 26, 2, 2020, 204-214. doi: 10.21608/zumj.2019.11299.1175
Anwar, P., Abd El-Rahman, M., Baiomy, T., Ashour, H. (2020). 'PREDICTION OF EARLY ANASTOMOTIC LEAKAGE FOLLOWING COLORECTAL CANCER SURGERY IN ZAGAZIG UNIVERSITY HOSPITALS', EKB Journal Management System, 26(2), pp. 204-214. doi: 10.21608/zumj.2019.11299.1175
Anwar, P., Abd El-Rahman, M., Baiomy, T., Ashour, H. PREDICTION OF EARLY ANASTOMOTIC LEAKAGE FOLLOWING COLORECTAL CANCER SURGERY IN ZAGAZIG UNIVERSITY HOSPITALS. EKB Journal Management System, 2020; 26(2): 204-214. doi: 10.21608/zumj.2019.11299.1175

PREDICTION OF EARLY ANASTOMOTIC LEAKAGE FOLLOWING COLORECTAL CANCER SURGERY IN ZAGAZIG UNIVERSITY HOSPITALS

Zagazig University Medical Journal
Article 2, Volume 26, Issue 2, March 2020, Page 204-214  XML PDF (190.65 K)
Document Type: Original Article
DOI: 10.21608/zumj.2019.11299.1175
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Authors
Pola Nagy Anwar email orcid 1; Mohammed Said Abd El-Rahman2; Taha Abd El-Wahab Baiomy2; Hassan Rabea Ashour2
1General Surgery Department, Faculty of Medicine, Zagazig University Hospitals, El-Sharkia, Egypt.
2General Surgery departments, Faculty of Medicine, Zagazig University.
Abstract
Background: Anastomotic leak (AL) is the most common unfavorable complication after colorectal surgery. Early discharge benefits the patient but carries a potential risk of developing AL. So the early diagnosis of AL is critical. Aim: To assess whether C-reactive protein (CRP) and Procalcitonin (PCT) will predict AL before early discharge. Methods: This study was carried out in Surgical-oncology Unit, General Surgery Department, Zagazig University Hospitals, during the period from May 2018 to November 2018. The study included 24 patients with Colorectal cancer undergoing elective open colorectal resection with anastomosis. CRP and PCT were measured pre-operatively, 8h after incision, and on the 3rd and 5th postoperative day (POD). 30-day readmissions, re-laparotomy, and mortality were recorded. Results: 5 patients had AL (20.8%). 5th day postoperative CRP and PCT were significantly lower in patients without AL than patients with AL. The present study revealed the diagnostic performance of CRP in the prediction of AL where 5th day CRP>198.23mg/mL had 100% sensitivity, 94.74% specificity, 83.3% positive predictive value, 100% negative predictive value and 95.8% accuracy in the prediction of AL. Also, the study revealed diagnostic performance of 5th day PCT in the prediction of AL where a cutoff of more than 1.212 ng/dl, 5th day PCT had 80% sensitivity, 100% specificity, 100% positive predictive value, 95% negative predictive value and 95.8% accuracy in prediction of AL. Conclusion: CRP and PCT measurements can positively identify patients at risk of AL with CRP being more accurate and a potentially powerful marker.
Keywords
colorectal cancer; Anastomosis; leak; C-reactive protein; Procalcitonin
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