Letrozole Versus Tomoxifen in Infertile Woman with Clomiphene Citrate Resistant Polycystic Ovarian Syndrome
Saad, A., Saleh, S., Mahmoud El-Melih, A., Sayer Dayer, M. (2023). Letrozole Versus Tomoxifen in Infertile Woman with Clomiphene Citrate Resistant Polycystic Ovarian Syndrome. EKB Journal Management System, 13(4), 311-316. doi: 10.21608/ebwhj.2023.44462.1112
Abd El-Haseib Salah Saad; Said Abd El-Atti Saleh; Asmaa Hazem Mahmoud El-Melih; Mohamed Zakaria Sayer Dayer. "Letrozole Versus Tomoxifen in Infertile Woman with Clomiphene Citrate Resistant Polycystic Ovarian Syndrome". EKB Journal Management System, 13, 4, 2023, 311-316. doi: 10.21608/ebwhj.2023.44462.1112
Saad, A., Saleh, S., Mahmoud El-Melih, A., Sayer Dayer, M. (2023). 'Letrozole Versus Tomoxifen in Infertile Woman with Clomiphene Citrate Resistant Polycystic Ovarian Syndrome', EKB Journal Management System, 13(4), pp. 311-316. doi: 10.21608/ebwhj.2023.44462.1112
Saad, A., Saleh, S., Mahmoud El-Melih, A., Sayer Dayer, M. Letrozole Versus Tomoxifen in Infertile Woman with Clomiphene Citrate Resistant Polycystic Ovarian Syndrome. EKB Journal Management System, 2023; 13(4): 311-316. doi: 10.21608/ebwhj.2023.44462.1112

Letrozole Versus Tomoxifen in Infertile Woman with Clomiphene Citrate Resistant Polycystic Ovarian Syndrome

Evidence Based Women's Health Journal
Article 1, Volume 13, Issue 4, November 2023, Page 311-316  XML PDF (370.06 K)
Document Type: Original Article
DOI: 10.21608/ebwhj.2023.44462.1112
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Authors
Abd El-Haseib Salah Saad1; Said Abd El-Atti Saleh1; Asmaa Hazem Mahmoud El-Melih email 2; Mohamed Zakaria Sayer Dayer1
1Department of Obstetrics & Gynecology, Faculty of Medicine, Menoufia University, Egypt
2Obstetrics & Gynecology department, Al Shohadaa General Hospital, Menoufia, Egypt
Abstract
Objectives: To compare the effects of Letrozole and Tamoxifen for induction of ovulation in clomiphene citrate resistant women with Polycystic Ovarian syndrome.
Patients and Methods: A prospective randomized study was conducted in the Department of Obstetrics & Gynecology of Menoufia University Hospital. The study was carried out on 80 clomiphene citrate resistant women with polycystic ovary syndrome divided into Group (1): received letrozole 2,5 mg tab orally twice per day from day 3 to day 7 of the menstrual cycle for three successive cycles (40 women, odd numbers). Group (2): received Tamoxifen 20 mg tab once per day from day 3 to day 7 of the menstrual cycle for three successive cycles (40 women, even numbers). In both groups, 10000 IU hCG was administrated when at least one mature follicle more than 18mm was observed during folliculometry.
Results: The mean number of follicles (≥18 mm) was higher in letrozole than tamoxifen group. Ovulation rate was significantly higher in letrozole than tamoxifen group (52.5% vs 20% ) .There were no statistically significant differences between both groups regarding pregnancy rate.
Conclusion: Letrozole was eminent than tamoxifen in achieving a higher ovulation rate and should be considered for clomiphene citrate resistant women with polycystic ovarian syndrome.
Keywords
Clomiphene citrate resistant; letrozole; polycystic ovarian syndrome; tamoxifen
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