Impact of Vitamin D Deficiency on ICSI cycle Outcome | ||||
| Evidence Based Women's Health Journal | ||||
| Article 2, Volume 13, Issue 4, November 2023, Page 317-321 PDF (341.73 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ebwhj.2023.177236.1225 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Amany Abdel Ghany1; Shahenda Saleh2; Abeer Omran  3; Samar Sharaf4; Amr Aboelfath2
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| 1Obstetrics and Gynaecology, Faculty of Medicine – Zagazig University, Egypt | ||||
| 2Lecturer of Obstetrics and Gynaecology, Faculty of Medicine – Zagazig University, Egypt | ||||
| 3Obstetrics and gynecology, Itay El Baroud General Hospital , Egypt | ||||
| 4Clinical pathology, Faculty of Medicine – Zagazig University, Egypt | ||||
| Abstract | ||||
| Background: Emerging data identifies critical roles for vitamin D and many areas of medicine are involved: regulation of cellular growth, immunity, central nervous system, cardiovascular diseases, and reproduction. Objective: To determine the impact of serum vitamin D level on ICSI cycle outcome. Design: A prospective cohort study. Methods: Patients who will undergo ICSI cycle with age ≤ 38 years , adequate ovarian reserve were included in this study., women with poor ovarian reserve and patients with freeze all cycles were excluded. Vitamin D Serum samples were obtained On the day of the ovum pick-up, participants were divided into 2 groups :Deficiency: (serum vitamin D ≤30ng/ml), Sufficiency: (serum vitamin D≥30ng/ml ).Quantitative B-hCG was done 14 days after emberyo transfer Result : A total of 135 women were included in the study after undergoing ICSI , women were divided into two groups as following :Group A:(n = 68) with serum vitamin D level ≥30 ng/ml and Group B:(n = 67) with serum vitamin D level < 30 ng/ml at day of ovum pick-up.. pregnancy was significantly higher in group A (76.5 %) compared to group B (58.2 %) with P-value < 0.05. With regards to pregnancy continuation there was significant increase in ongoing pregnancy among group A (88.5 %) compared to group B (61.5 %) and significant decrease in the number of aborted cases among group A (11.5 %) compared to group B (38.5 %) with P-value < 0.05. Conclusions: Vitamin D serum level may play a role in ICSI cycle out come . and it seems to valuable to adjust its level in patients with deficiency before starting their ICSI cycle | ||||
| Keywords | ||||
| Abortion rate; ICSI; infertility; pregnancy rate; vitamin D | ||||
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