Association of IL-6 rs1800795 and IL-1 β rs16944 polymorphisms with non-small cell lung cancer in the Egyptian population: a pilot study
Metwally, Y., Zahran, R., Elsadda, R., Refaat, S., Elsaid, A. (2023). Association of IL-6 rs1800795 and IL-1 β rs16944 polymorphisms with non-small cell lung cancer in the Egyptian population: a pilot study. EKB Journal Management System, 13(3), 8-15. doi: 10.21608/sjdfs.2023.248290.1144
Yomna Fawzy Metwally; Rasha Fikry Zahran; Rana Ramzy Elsadda; Sherif Refaat; Afaf Mohammed Elsaid. "Association of IL-6 rs1800795 and IL-1 β rs16944 polymorphisms with non-small cell lung cancer in the Egyptian population: a pilot study". EKB Journal Management System, 13, 3, 2023, 8-15. doi: 10.21608/sjdfs.2023.248290.1144
Metwally, Y., Zahran, R., Elsadda, R., Refaat, S., Elsaid, A. (2023). 'Association of IL-6 rs1800795 and IL-1 β rs16944 polymorphisms with non-small cell lung cancer in the Egyptian population: a pilot study', EKB Journal Management System, 13(3), pp. 8-15. doi: 10.21608/sjdfs.2023.248290.1144
Metwally, Y., Zahran, R., Elsadda, R., Refaat, S., Elsaid, A. Association of IL-6 rs1800795 and IL-1 β rs16944 polymorphisms with non-small cell lung cancer in the Egyptian population: a pilot study. EKB Journal Management System, 2023; 13(3): 8-15. doi: 10.21608/sjdfs.2023.248290.1144

Association of IL-6 rs1800795 and IL-1 β rs16944 polymorphisms with non-small cell lung cancer in the Egyptian population: a pilot study

Scientific Journal for Damietta Faculty of Science
Volume 13, Issue 3, December 2023, Page 8-15  XML PDF (423.15 K)
Document Type: Original articles
DOI: 10.21608/sjdfs.2023.248290.1144
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Authors
Yomna Fawzy Metwally email 1; Rasha Fikry Zahranorcid 2; Rana Ramzy Elsaddaorcid 2; Sherif Refaat3; Afaf Mohammed Elsaid4
1Biochemistry Department, Faculty of Science, Damietta University, Damietta, Egypt.
2Biochemistry Department, Faculty of Science, Damietta University, Damietta, Egypt
3Oncology Department, Oncology Center, Mansoura University, Mansoura, Egypt.
4Genetics Unit, Children Hospital, Mansoura University, Mansoura, Egypt.
Abstract
Lung cancer is a serious health and life issue, with the highest rates of incidence and mortality in the world. It is now clear that inflammation is a key factor involved in all aspects of carcinogenesis, notably lung cancer development. Genetic changes, including polymorphisms in inflammatory genes, are supposed to play a significant role in increasing lung cancer risk. In this study, we aim to investigate the association of IL-6 rs1800795 and IL-1β rs16944 polymorphisms with non-small cell lung cancer (NSCLC) development in the Egyptian population. The study design was composed of 100 NSCLC cases and 100 controls, which were genotyped using the ARMS-PCR technique, electrophoresed on a 2.5% agarose gel, and visualized using ethidium bromide under ultraviolet illumination. The IL-1β rs16944 genotypes were significantly different in NSCLC patients as compared to healthy controls (p = 0.032). Whereas the genotypes and alleles of the IL-6 rs1800795 were not significantly linked to NSCLC incidence (p = 0.726; p = 0.822, respectively). To our best knowledge, this study aimed to uncover the great impact of IL-1β rs16944 genotypes on NSCLC development in the Egyptian population; thus, it may be a gateway for earlier NSCLC prevention.
Keywords
Lung cancer; polymorphism; IL-6; IL-1β Egypt
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