Dexmedetomidine versus fentanyl in intraoperative neuromuscular monitoring using propofol based total intravenous anesthesia regimen in kyphoscoliosis correction surgery
Panse, N., Kale, J., Phalke, T., Bhojane, U. (2021). Dexmedetomidine versus fentanyl in intraoperative neuromuscular monitoring using propofol based total intravenous anesthesia regimen in kyphoscoliosis correction surgery. EKB Journal Management System, 13(1), -. doi: 10.1186/s42077-021-00190-2
Neha Amey Panse; Jyoti Vishnu Kale; Tejaswini Lalasaheb Phalke; Utkarsha Pradeep Bhojane. "Dexmedetomidine versus fentanyl in intraoperative neuromuscular monitoring using propofol based total intravenous anesthesia regimen in kyphoscoliosis correction surgery". EKB Journal Management System, 13, 1, 2021, -. doi: 10.1186/s42077-021-00190-2
Panse, N., Kale, J., Phalke, T., Bhojane, U. (2021). 'Dexmedetomidine versus fentanyl in intraoperative neuromuscular monitoring using propofol based total intravenous anesthesia regimen in kyphoscoliosis correction surgery', EKB Journal Management System, 13(1), pp. -. doi: 10.1186/s42077-021-00190-2
Panse, N., Kale, J., Phalke, T., Bhojane, U. Dexmedetomidine versus fentanyl in intraoperative neuromuscular monitoring using propofol based total intravenous anesthesia regimen in kyphoscoliosis correction surgery. EKB Journal Management System, 2021; 13(1): -. doi: 10.1186/s42077-021-00190-2

Dexmedetomidine versus fentanyl in intraoperative neuromuscular monitoring using propofol based total intravenous anesthesia regimen in kyphoscoliosis correction surgery

Ain-Shams Journal of Anesthesiology
Volume 13, Issue 1, January 2021  XML PDF (837.54 K)
DOI: 10.1186/s42077-021-00190-2
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Authors
Neha Amey Panseorcid ; Jyoti Vishnu Kale; Tejaswini Lalasaheb Phalke email ; Utkarsha Pradeep Bhojane
Abstract
Background
Intraoperative neuromuscular monitoring (IONM) is used to reduce the risk of postoperative neurological deficit in patients undergoing kyphoscoliosis correction surgery. Somatosensory evoked potentials (SSEPs) are among the several techniques developed by neurophysiologists to increase the sensitivity of intraoperative monitoring. We administered total intravenous anesthesia (TIVA) to 20 patients undergoing kyphoscoliosis deformity correction surgeries: group A: propofol and dexmedetomidine and group B: propofol and fentanyl. The primary objective of our study was to compare the effect of dexmedetomidine and fentanyl on intraoperative hemodynamic parameters and their interference with SSEP’s readings. The secondary objective was to assess the total intraoperative requirement of inhalational anesthetic agents, quality of surgical field, and the cost-effectiveness of either regimen.
Results
Intraoperative hemodynamic stability, analgesia, surgical field, and cost-effectiveness (due to reduced requirement of sevoflurane) were better with dexmedetomidine than fentanyl. SSEPs were successfully recorded with both the drugs while the requirement of inhalation anesthetic agents was significantly reduced in the dexmedetomidine group than in the fentanyl group. There were no injuries while recording SSEPs. The latency and amplitude of SSEPs were maintained throughout either group. No intraoperative awakening or awareness was noted (bispectral index was maintained in the range of 40 to 60). No postoperative neurological deficit was noted in any patient.
Conclusions
Both dexmedetomidine and fentanyl can be successfully used in propofol-based TIVA for SSEP monitoring in kyphoscoliosis correction surgeries, but the better analgesic profile, ease of maintaining stable hemodynamics with a significant reduction in inhalational agent requirement, and opioid-sparing effect by dexmedetomidine make it a more desirable agent to be used in propofol-based TIVA.
Keywords
Dexmedetomidine; Fentanyl; Kyphoscoliosis; Propofol somatosensory-evoked potential (SSEP); Total intravenous anesthesia (TIVA)
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