A multicentric study to correlate severity of disease and vaccine in COVID-19 pandemic
Patel, A., Solanki, R., Channwal, H., Dave, V., Prajapati, A., Patel, M. (2022). A multicentric study to correlate severity of disease and vaccine in COVID-19 pandemic. EKB Journal Management System, 14(1), -. doi: 10.1186/s42077-022-00266-7
Ankita Rushik Patel; Rekha Nilesh Solanki; Heena Sunil Channwal; Viral Rajanikant Dave; Arpit Chelabhai Prajapati; Mansi Maulik Patel. "A multicentric study to correlate severity of disease and vaccine in COVID-19 pandemic". EKB Journal Management System, 14, 1, 2022, -. doi: 10.1186/s42077-022-00266-7
Patel, A., Solanki, R., Channwal, H., Dave, V., Prajapati, A., Patel, M. (2022). 'A multicentric study to correlate severity of disease and vaccine in COVID-19 pandemic', EKB Journal Management System, 14(1), pp. -. doi: 10.1186/s42077-022-00266-7
Patel, A., Solanki, R., Channwal, H., Dave, V., Prajapati, A., Patel, M. A multicentric study to correlate severity of disease and vaccine in COVID-19 pandemic. EKB Journal Management System, 2022; 14(1): -. doi: 10.1186/s42077-022-00266-7

A multicentric study to correlate severity of disease and vaccine in COVID-19 pandemic

Ain-Shams Journal of Anesthesiology
Volume 14, Issue 1, January 2022  XML PDF (855.81 K)
DOI: 10.1186/s42077-022-00266-7
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Authors
Ankita Rushik Patel email orcid ; Rekha Nilesh Solanki; Heena Sunil Channwal; Viral Rajanikant Dave; Arpit Chelabhai Prajapati; Mansi Maulik Patelorcid
Abstract
Background
The purpose of the study was to find out correlation between severity of disease and vaccine in COVID-19 pandemic. Primary objective was to know occurrence of post-vaccination breakthrough infections in hospitalized patients and secondary objective was to know of COVID-19 vaccine to prevent severe infection, morbidity, and mortality of patients. This retrospective observational multicentric study included 325 confirmed COVID-19 patients on NRBM/BIPAP/ventilator admitted in high dependency unit (HDU)/intensive care unit (ICU) were divided into based on severity of symptoms and vaccination status. We included adult patients having positive RTPCR (reverse transcription polymerase chain reaction) COVID-19 test/high-resolution computed tomography scan (HRCT) thorax suggestive of COVID-19 pneumonia. Patients who developed adverse reaction post-vaccination, pregnant patient, and lactating mother were excluded from the study.
Results
Total 325 confirmed COVID-19-positive patients were studied. Statistical analysis with SPSS version 26 and data were analyzed by chi-square test and value < 0.05 were considered as significant. Total duration of hospital stay was less in vaccinated patients compared to non-vaccinated patients. Oxygen requirement was also less in vaccinated patients. Vaccinated patients developed less severe infection than non-vaccinated patients.
Conclusions
COVID-19 vaccination is very effective against severity of disease. It reduces hospitalization, oxygen requirement, and mortality.
Keywords
COVID-19 vaccine; severity of disease; pandemic
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