Measurement Visfatin Level and Its Genetic Polymorphisms (rs61330082) in Women with Polycystic Ovary Syndrome With and Without Insulin Resistance
Noori, D., Omear, H., Mohsin, S. (2023). Measurement Visfatin Level and Its Genetic Polymorphisms (rs61330082) in Women with Polycystic Ovary Syndrome With and Without Insulin Resistance. EKB Journal Management System, 15(2), 873-881. doi: 10.21608/eajbsc.2023.330322
Dhuha S. Noori; Hadeel A. Omear; Saria N. Mohsin. "Measurement Visfatin Level and Its Genetic Polymorphisms (rs61330082) in Women with Polycystic Ovary Syndrome With and Without Insulin Resistance". EKB Journal Management System, 15, 2, 2023, 873-881. doi: 10.21608/eajbsc.2023.330322
Noori, D., Omear, H., Mohsin, S. (2023). 'Measurement Visfatin Level and Its Genetic Polymorphisms (rs61330082) in Women with Polycystic Ovary Syndrome With and Without Insulin Resistance', EKB Journal Management System, 15(2), pp. 873-881. doi: 10.21608/eajbsc.2023.330322
Noori, D., Omear, H., Mohsin, S. Measurement Visfatin Level and Its Genetic Polymorphisms (rs61330082) in Women with Polycystic Ovary Syndrome With and Without Insulin Resistance. EKB Journal Management System, 2023; 15(2): 873-881. doi: 10.21608/eajbsc.2023.330322

Measurement Visfatin Level and Its Genetic Polymorphisms (rs61330082) in Women with Polycystic Ovary Syndrome With and Without Insulin Resistance

Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology
Volume 15, Issue 2, December 2023, Page 873-881  XML PDF (415.53 K)
Document Type: Original Article
DOI: 10.21608/eajbsc.2023.330322
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Authors
Dhuha S. Noori; Hadeel A. Omear; Saria N. Mohsin
Biology Department, College of Science, Tikrit University, Iraq.
Abstract
Bachground: Polycystic ovary syndrome (PCOS) is a common condition that often leads to metabolic complications such as insulin resistance (IR) and obesity. Visfatin is a peptide that plays a role in endocrine, autocrine, and paracrine functions. Methods: Samples were collected from 90 women aged 16 to 40 years, divided into two groups. The PCOS group comprised 60 samples, with 30 women who had insulin resistance and 30 women who did not. The healthy group included 30 samples. The visfatin levels for all participants and performed genotyping for specific regions of the visfatin (rs1330082) gene using Real-time PCR were measured. The statistical significance is defined as p ≤ 0.05 for all comparisons. Results: The results showed that women with PCOS and insulin resistance had significantly higher levels of serum visfatin compared to other studies (6.640±0.3886, p <0.0001). However, there was no significant difference regarding the frequency of visfatin rs1330082 allele between the study groups. Conclusion: The research indicates that measuring serum visfatin levels could be a helpful tool for predicting insulin resistance in women with PCOS. However, we did not find any significant correlation between visfatin allele frequencies (rs1330082) and susceptibility to PCOS when compared to healthy controls.
Keywords
Visfatin; rs1330082; polycystic ovary syndrome, insulin resistance
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