Evaluation of Paraoxonase 1 Serum Level in Male Androgenetic Alopecia Patients | ||||
| Benha Journal of Applied Sciences | ||||
| Article 9, Volume 8, Issue 10, October 2023, Page 71-74 PDF (405.64 K) | ||||
| Document Type: Original Research Papers | ||||
| DOI: 10.21608/bjas.2023.240521.1261 | ||||
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| Authors | ||||
Shimaa Desokey  1; Khaled Monib1; Mohamed Hussein1; Amira Mohamed2
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| 1Dermatology, Venereology and Andrology Dept., Faculty of Medicine, Benha Univ. | ||||
| 2clinical and Chemical Pathology Dept., Faculty of Medicine, Benha Univ. | ||||
| Abstract | ||||
| Background: Male androgenetic alopecia (AGA) is characterized by progressive hair loss. Oxidative stress has been noticed in dermal papilla cells of AGA patients. Paraoxonase 1 (PON1) plays an important role as an antioxidant by preventing oxidation of low-density lipoprotein (LDL). PON1 serum concentration is influenced by inflammatory changes and serum levels of oxidized LDL. The present study aimed to measure serum PON1 in male AGA patients and compare its level with healthy controls. Patients and Methods: This case-control study included sixty male patients complaining of AGA and twenty age and sex healthy volunteers as a control. They were selected from those attending the Outpatient Clinic of Dermatology Department of Benha University Hospitals during the period from April 2020 to December 2021. Results: Serum PON1 and HDL were significantly lower in AGA patients than controls Conclusion: The study concluded that the lower level of PON1 reported in AGA patients may be due to increased oxidative stress. | ||||
| Keywords | ||||
| Serum Paraoxonase 1; Male androgenetic alopecia; PON1; AGA | ||||
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