Intercellular Adhesion Molecule-1 (ICAM-1) gene polymorphism in Patients with Acne Vulgaris | ||||
Benha Journal of Applied Sciences | ||||
Article 5, Volume 8, Issue 11, November 2023, Page 37-40 PDF (306.35 K) | ||||
Document Type: Original Research Papers | ||||
DOI: 10.21608/bjas.2023.244050.1273 | ||||
View on SCiNiTO | ||||
Authors | ||||
Adel Ibrahim1; Amany Mostafa1; Naglaa Al-Husseini2; Suzan Amr 1 | ||||
1Dermatology, Venereology and Andrology Dept., Faculty of Medicine, Benha University | ||||
2Medical Biochemistry Dept., Faculty of Medicine, Benha University | ||||
Abstract | ||||
Background: ICAM-Intercellular adhesion molecule-1 (ICAM-1) is a gene that encodes a glycoprotein found on the surface of cells that helps them stick together and respond to immunological stimuli. Several research have looked at whether variations in the ICAM-1 gene have a role in acne vulgaris susceptibility (AV). The purpose of this research was to examine ICAM-1 gene polymorphism in acne vulgaris patients. Methods: Fifty people with AV and 30 people who seemed to be healthy served as controls in this prospective case-control study. Genotyping of ICAM-1 gene polymorphism using PCR necessitated a clinical evaluation and blood sample from all individuals. Results: In regards to the ICAM-1 gene's genotypes and alleles: Everyone, including patients and controls, were genotyped. Two percent of AV patients had the AA genotype, thirty percent had the AG genotype, and fifty-six percent had the GG genotype. Forty percent of healthy controls had the AA genotype, 46.7% the AG genotype, and 13.3% the GG genotype. Acne vulgaris was strongly associated with the GG genotype. In conclusion, ICAM-1 gene polymorphism may increase AV patients' vulnerability. | ||||
Keywords | ||||
Acne vulgaris; intercellular adhesion molecule 1; and gene variants are some related terms | ||||
Statistics Article View: 34 PDF Download: 76 |
||||