Development and characterization of nanostructure lipid carrier for anti-hepatitis-C virus drug | ||||
Journal of advanced Biomedical and Pharmaceutical Sciences | ||||
Article 2, Volume 7, Issue 1, January 2024, Page 18-25 PDF (637.74 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/jabps.2023.234602.1202 | ||||
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Authors | ||||
Mahmoud EL-Badry 1; Ominia Ali Mahmoud2; Dina Fathalla3; Gamal EL-Gendy4 | ||||
1Dept of Pharmaceutics Faculty of Pharmacy Assiut University | ||||
2Department of pharmaceutics, Faculty of pharmacy, Sohag University | ||||
3Faculty of Pharmacy, Assiut university | ||||
4Department of Pharmaceutics, Faculty of pharmacy, Assiut University | ||||
Abstract | ||||
Abstract Velpatasvir (VLP) as, a medication used to treat hepatitis-C virus (HCV). It has a very low oral bioavailability (25%). The aim of the current work is to prepare VLP loaded nanostructured lipid carriers (VLP-NLCs) as a potential way to enhance VLP aqueous solubility and bioavailability and increase its efficacy. The preparation of VLP-NLCs was carried out using the emulsification - solvent evaporation method, followed by ultrasonication. The prepared nanocarrier was examined for its particle size, zeta potential, entrapment efficiency and in-vitro drug release of the selected formula. VLP-NLCs displayed narrow size distribution, spherical morphologies that were nanosized (105 ± 2.3 nm), and significant drug entrapment efficiencies (> 80%). Particle size ranged between 105 ± 2.3 to 1399 ± 2.8 nm and zeta potential between -14.6 ± 0.2 to -46.0 ± 1.1 mV. High entrapping efficiency was obtained due to incorporation of liquid lipid. The In Vitro release showed prolonged time dependent release. NLC 6 had the best results among the eight prepared formulae. These findings show that NLC is a potential carrier to improve the solubility of drug and enhance its bioavailability. | ||||
Keywords | ||||
Velpatasvir; HCV; Nanostructured lipid carriers (NLCs); particle size; in-vitro drug release | ||||
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