ASSESMENT OF THE THERAPUTIC EFECT OF LATE AZITHROMYCIN TREATMENT ON CHRONIC MURINE TOXOPLASMOSIS | ||||
Journal of the Egyptian Society of Parasitology | ||||
Article 10, Volume 53, Issue 3, December 2023, Page 491-498 PDF (1.01 MB) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/jesp.2023.331734 | ||||
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Authors | ||||
GEHAN A. RASHED1; MONA E. NASR1; ATEF H. ABD EL HAMID1; NAGWA S. M. ALY1; ASHRAF M. A. BARAKAT2; KAWKAB A. AHMED3; SAFAA H. YOUSSIF1; GHADA H. OMAR1 | ||||
1Department of Parasitology, Faculty of Medicine, Benha University | ||||
2Department of Zoonotic Diseases, National Research Centre, Cairo 12622, Egypt | ||||
3Department of Pathology, Faculty of Veterinary Medicine, Cairo University, Giza, 12211, Egypt | ||||
Abstract | ||||
Toxoplasmosis is a widespread, neglected disease with significant morbidity and mortality. The current study aimed to investigate the potential effectiveness of azithromycin against the cystogenic Me 49 nonvirulent strain of Toxoplasma gondii after the 6th week post-infection (PI) in chronically infected mice. Fifty laboratory-bred female Swiss albino mice were divided into five groups: G1: Non- Infected, G2: Infected non-treated, G3: Infected and treated by azithromycin 200 mg/kg after the 6th week PI for 3 days, G4: Infected and treated by azithromycin 200 mg/kg after the 6th week PI for 10 days and G5: Infected and treated by spiramycin 200 mg/kg after the 6th week PI for 2 weeks, brain cysts number, size and histopathological changes were evaluated after 2 months. The results showed that treating mice after the 6th week post-infection with azithromycin for 10 days reduced number and size of brain cysts by 64% & 30%, respectively, but without significant difference as compared with spiramycin-treated ones. Azithromycin treatment for 3 days achieved a greater reduction (34%) in brain cyst size than the group treated with azithromycin for 10 days. But, it caused the least reduction in brain cyst number (10%). Azithromycin treatment for 10 days improved the histopathological changes in cerebral toxoplasmosis. | ||||
Keywords | ||||
Mice; Azithromycin; Spiramycin; Toxoplasma gondii; Treatment | ||||
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