Efficacy of Laser-Assisted Hatching on Pregnancy and Live-Birth Rates of Human Frozen-Thawed Embryos
El-Toukhy, S., El-Desouky, M., Mansour, R., Abdur-Rahman, M. (2023). Efficacy of Laser-Assisted Hatching on Pregnancy and Live-Birth Rates of Human Frozen-Thawed Embryos. EKB Journal Management System, 40(1), 198-212. doi: 10.21608/jsrs.2023.331811
Shorouk El-Toukhy; Mohamed Ali El-Desouky; Ragaa Taha Mansour; Mariam Abdur-Rahman. "Efficacy of Laser-Assisted Hatching on Pregnancy and Live-Birth Rates of Human Frozen-Thawed Embryos". EKB Journal Management System, 40, 1, 2023, 198-212. doi: 10.21608/jsrs.2023.331811
El-Toukhy, S., El-Desouky, M., Mansour, R., Abdur-Rahman, M. (2023). 'Efficacy of Laser-Assisted Hatching on Pregnancy and Live-Birth Rates of Human Frozen-Thawed Embryos', EKB Journal Management System, 40(1), pp. 198-212. doi: 10.21608/jsrs.2023.331811
El-Toukhy, S., El-Desouky, M., Mansour, R., Abdur-Rahman, M. Efficacy of Laser-Assisted Hatching on Pregnancy and Live-Birth Rates of Human Frozen-Thawed Embryos. EKB Journal Management System, 2023; 40(1): 198-212. doi: 10.21608/jsrs.2023.331811

Efficacy of Laser-Assisted Hatching on Pregnancy and Live-Birth Rates of Human Frozen-Thawed Embryos

Journal of Scientific Research in Science
Volume 40, Issue 1, 2023, Page 198-212  XML PDF (1.16 MB)
Document Type: Original Article
DOI: 10.21608/jsrs.2023.331811
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Authors
Shorouk El-Toukhy1; Mohamed Ali El-Desouky2; Ragaa Taha Mansour1; Mariam Abdur-Rahman email orcid 2
1Egyptian IVF-ET Center, Cairo, Egypt.
2Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt.
Abstract
 Unexplained repeated in-vitro fertilization (IVF) failure is a major problem that faces both genders. The present study aims to estimate the influence of the laser-assisted hatching (LAH) technique on implantation, clinical pregnancy and live-birth rates using human cryopreserved–thawed embryos produced by intracytoplasmic sperm injection (ICSI). Materials and methods: A total of 208 subjects was divided randomly into 100 subjects in the control group (Non-LAH), in which the uterine frozen embryo transfer (FET) was done directly; and 108 subjects in LAH group, in which laser shots were applied on day-3 frozen-thawed embryos before uterine transfer. All groups were further subdivided into three female age categories (22-30; 31-35 & 36-40 years). Number of mature, fertilized oocytes, fertilization, clinical pregnancy and live-birth rates were determined according to age distribution. Results: Both pregnancy (37.0 %) and live-birth (57.5 %) rates in LAH group were insignificantly lower than Non-LAH control group having pregnancy and live-birth rates of (45.0 % and 73.3 %, respectively). LAH caused a mild increase in clinical outcomes in females aged over 36 years, but in contrast, no improvement was observed in younger subjects. Conclusion: Our experimental study did not support using LAH as a routine strategy in frozen-thawed embryo transfer cycles.
Keywords
In-vitro fertilization; ICSI; Laser-assisted hatching; Frozen embryos; Pregnancy
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