Triglycerides/High Density Lipoprotein-Cholesterol Ratio as a Novel Marker of Atherosclerosis in Patients with Acute Coronary Syndrome. | ||||
| NILES journal for Geriatric and Gerontology | ||||
| Volume 7, Issue 1, January 2024, Page 152-165 PDF (440.95 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/niles.2023.247949.1080 | ||||
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| Authors | ||||
Mohamed HAE Mohamed Elrashidy   1; Usama Ahmed Arafa2; Nayel Zaki2; Fatma Ahmed2
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| 1Internal medicine department, cardiology unit, Faculty of Medicine, Sohag University, Sohag, Egypt | ||||
| 2Department of Internal Medicine, Faculty of Medicine, Sohag University, Sohag, Egypt | ||||
| Abstract | ||||
| Background: A high serum TG/HDL-C ratio has been determined to be a cardiovascular disease (CVD) and mortality risk factor. Aim: ACS individuals' Triglycerides/High Density Lipoprotein-Cholesterol Ratio will be measured as a potential new measure of atherosclerosis. Methods: This cross sectional trial included 200 cases with ACS. All participants subjected to full history taking, clinical assessment, laboratory investigations (CK-MB), high-sensitive cardiac troponin (hs-cTn), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), Blood urea level, serum creatinine & (eGFR), Electrocardiogram (ECG) & Echocardiography. Depending on the values of the lipid profile TGs/HDL-C ratio will be calculated. Results: This study included 200 patients. Participants were separated into 3 groups: (Group A: n= 24 "12%", cases with unstable angina; Group B: n=124 "62%", patients with STEMI and Group C: n= 52 "26%", patients with NSTEMI). Regarding TG/HDL-C ratio, it ranged from 1.1 to 33 with mean (±SD) was 4.44± 3.26. Most cases (85.5%) had high ratio. By comparing TG /HDL ratio related to diagnosis. It was noticed non-significant differences between NSTEMI, STEMI and UA regarding TG /HDL-c ratio (p>0.05) Conclusion: There was a strong connection among a raised Triglycerides/High Density Lipoprotein-Cholesterol Ratio & the existence of high risk atheromatous plaques in individuals with ACS. Therefore, the ratio of TG to HDL-C may be a candidate for use as a biomarker in determining the presence of atherosclerosis in patients diagnosed with Acute Coronary Syndrome. | ||||
| Keywords | ||||
| Acute Coronary Syndrome; Triglycerides/High Density Lipoprotein-Cholesterol Ratio; Atherosclerosis | ||||
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