Metformin Reduces the Risk of Diabetic Neuropathy Among Egyptian Type 2 Diabetic Patients: A Case-Control Study
Hicham, Y., Sayed, R., Abdelsalam Besibes, M., Mahfouz, A., El Wakeel, L. (2023). Metformin Reduces the Risk of Diabetic Neuropathy Among Egyptian Type 2 Diabetic Patients: A Case-Control Study. EKB Journal Management System, 7(2), 432-439. doi: 10.21608/aps.2023.250911.1145
Yomne Hicham; Rana Sayed; Mona Abdelsalam Besibes; Amr A Mahfouz; Lamia El Wakeel. "Metformin Reduces the Risk of Diabetic Neuropathy Among Egyptian Type 2 Diabetic Patients: A Case-Control Study". EKB Journal Management System, 7, 2, 2023, 432-439. doi: 10.21608/aps.2023.250911.1145
Hicham, Y., Sayed, R., Abdelsalam Besibes, M., Mahfouz, A., El Wakeel, L. (2023). 'Metformin Reduces the Risk of Diabetic Neuropathy Among Egyptian Type 2 Diabetic Patients: A Case-Control Study', EKB Journal Management System, 7(2), pp. 432-439. doi: 10.21608/aps.2023.250911.1145
Hicham, Y., Sayed, R., Abdelsalam Besibes, M., Mahfouz, A., El Wakeel, L. Metformin Reduces the Risk of Diabetic Neuropathy Among Egyptian Type 2 Diabetic Patients: A Case-Control Study. EKB Journal Management System, 2023; 7(2): 432-439. doi: 10.21608/aps.2023.250911.1145

Metformin Reduces the Risk of Diabetic Neuropathy Among Egyptian Type 2 Diabetic Patients: A Case-Control Study

Archives of Pharmaceutical Sciences Ain Shams University
Volume 7, Issue 2, December 2023, Page 432-439  XML PDF (350.28 K)
Document Type: Original Article
DOI: 10.21608/aps.2023.250911.1145
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Authors
Yomne Hicham1; Rana Sayed email orcid 1; Mona Abdelsalam Besibes2; Amr A Mahfouz3; Lamia El Wakeelorcid 1
1Department of Clinical Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt
2Department of Internal Medicine, Endocrinology and Metabolism, Faculty of Medicine, Ain Shams University, Cairo, Egypt
3Department of Internal Medicine, Endocrinology Department, National Institute of Diabetes and Endocrinology, Cairo, Egypt
Abstract
Aim: This study aimed to investigate the association of different patient factors on the occurrence of diabetic peripheral neuropathy (DPN) among type 2 diabetes mellitus patients.
Methods: A case-control study was conducted on a total sample of 180 Egyptian type 2 diabetic patients. A full medical, medication, social, and family history was collected for the recruited sample. Glycated hemoglobin, lipid profile, and microalbuminuria were assessed.
Results: Among 180 patients recruited, 52 patients suffered from DPN. Low density-lipoprotein cholesterol (LDL-C) and total cholesterol (TC) were higher among patients suffering from DPN (p-value = 0.007 and 0.005, respectively). Metformin usage was the only factor that showed a significant decrease in the odds of developing DPN (odds ratio= 0.511, 95% confidence interval= 0.264- 0.911). Subgroup analysis showed that metformin decreased DPN among males rather than females (p-value = 0.006 vs 0.616, respectively).
Conclusion: Serum LDL-C and TC are both determinants for increased risk of DPN among type 2 diabetic patients. Metformin usage decreases DPN in a sex-specific dimorphic fashion where females are less liable to the protective effect of metformin against DPN.
Keywords
Diabetes Mellitus; Diabetic Neuropathy; Metformin; Egyptian Population; Cholesterol; Sex-Specific Response
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