Metformin Reduces the Risk of Diabetic Neuropathy Among Egyptian Type 2 Diabetic Patients: A Case-Control Study | ||||
Archives of Pharmaceutical Sciences Ain Shams University | ||||
Volume 7, Issue 2, December 2023, Page 432-439 PDF (350.28 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/aps.2023.250911.1145 | ||||
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Authors | ||||
Yomne Hicham1; Rana Sayed 1; Mona Abdelsalam Besibes2; Amr A Mahfouz3; Lamia El Wakeel 1 | ||||
1Department of Clinical Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt | ||||
2Department of Internal Medicine, Endocrinology and Metabolism, Faculty of Medicine, Ain Shams University, Cairo, Egypt | ||||
3Department of Internal Medicine, Endocrinology Department, National Institute of Diabetes and Endocrinology, Cairo, Egypt | ||||
Abstract | ||||
Aim: This study aimed to investigate the association of different patient factors on the occurrence of diabetic peripheral neuropathy (DPN) among type 2 diabetes mellitus patients. Methods: A case-control study was conducted on a total sample of 180 Egyptian type 2 diabetic patients. A full medical, medication, social, and family history was collected for the recruited sample. Glycated hemoglobin, lipid profile, and microalbuminuria were assessed. Results: Among 180 patients recruited, 52 patients suffered from DPN. Low density-lipoprotein cholesterol (LDL-C) and total cholesterol (TC) were higher among patients suffering from DPN (p-value = 0.007 and 0.005, respectively). Metformin usage was the only factor that showed a significant decrease in the odds of developing DPN (odds ratio= 0.511, 95% confidence interval= 0.264- 0.911). Subgroup analysis showed that metformin decreased DPN among males rather than females (p-value = 0.006 vs 0.616, respectively). Conclusion: Serum LDL-C and TC are both determinants for increased risk of DPN among type 2 diabetic patients. Metformin usage decreases DPN in a sex-specific dimorphic fashion where females are less liable to the protective effect of metformin against DPN. | ||||
Keywords | ||||
Diabetes Mellitus; Diabetic Neuropathy; Metformin; Egyptian Population; Cholesterol; Sex-Specific Response | ||||
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