Anti-obesity action of green tea extract and curcumin: Role of c1q/TNF-related protein-12 (CTRP-12) and caspase-2. | ||||
Bulletin of Pharmaceutical Sciences Assiut University | ||||
Articles in Press, Accepted Manuscript, Available Online from 25 December 2023 | ||||
Document Type: Original Article | ||||
DOI: 10.21608/bfsa.2023.223645.1827 | ||||
View on SCiNiTO | ||||
Authors | ||||
Mohamed Hussein1; Manal Mandour2; Sary AbdElghaffar Nasr3; Abdel-Raheim Meki2, 4; Michel E. Fakhry 2 | ||||
1Department of Biochemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt | ||||
2Department of Medical Biochemistry, Faculty of Medicine, Assiut University, Assiut, Egypt | ||||
3Department of Pathology, Faculty of Veterinary Medicine, Assiut University, Assiut, Egypt. | ||||
4Department of Biochemistry, Faculty of Pharmacy, Sphinx University, New Assiut, Egypt | ||||
Abstract | ||||
Background: The prevalence of obesity is increasing. It is regarded to be among of the world's biggest health issues and the primary factor in metabolic syndrome, a group of illnesses including hypertension, diabetes mellitus, and dyslipidemia. Many studies proved the efficacy of dietary polyphenols ascurcuminand green tea extractin ameliorating obesity and its correlated disorders. Methods: Our work was the first to explore the impact of green tea extract and curcumin on the insulin-sensitizing anti-inflammatory adipokine C1q/ TNF-related protein-12 (CTRP-12)serum level measured by ELISA and expression of caspase-2 in white adipose tissue invivo measured by qRT-PCR. Results: We found that both green tea extract and curcumin elevated serum CTRP-12 level. Moreover, they stimulated adipocytes apoptosis via increasing the expression of caspase-2 decreasing adiposity. Conclusion: The current study concludes that green tea extract and curcumin have prophylactic effect against obesity and obesity-related disorders. Keywords: high-fat diet, caspase-2, CTRP-12, green tea extract, curcumin. | ||||
Keywords | ||||
high-fat diet; caspase-2; CTRP-12; green tea extract; curcumin | ||||
Statistics Article View: 54 |
||||