ANTI-OBESITY ACTION OF GREEN TEA EXTRACT AND CURCUMIN: ROLE OF C1Q/TNF-RELATED PROTEIN-12 (CTRP-12) AND CASPASE-2.
Hussein, M., Mandour, M., AbdElghaffar Nasr, S., Meki, A., Fakhry, M. (2024). ANTI-OBESITY ACTION OF GREEN TEA EXTRACT AND CURCUMIN: ROLE OF C1Q/TNF-RELATED PROTEIN-12 (CTRP-12) AND CASPASE-2.. EKB Journal Management System, 47(1), 345-362. doi: 10.21608/bfsa.2023.223645.1827
Mohamed Hussein; Manal Mandour; Sary AbdElghaffar Nasr; Abdel-Raheim Meki; Michel E. Fakhry. "ANTI-OBESITY ACTION OF GREEN TEA EXTRACT AND CURCUMIN: ROLE OF C1Q/TNF-RELATED PROTEIN-12 (CTRP-12) AND CASPASE-2.". EKB Journal Management System, 47, 1, 2024, 345-362. doi: 10.21608/bfsa.2023.223645.1827
Hussein, M., Mandour, M., AbdElghaffar Nasr, S., Meki, A., Fakhry, M. (2024). 'ANTI-OBESITY ACTION OF GREEN TEA EXTRACT AND CURCUMIN: ROLE OF C1Q/TNF-RELATED PROTEIN-12 (CTRP-12) AND CASPASE-2.', EKB Journal Management System, 47(1), pp. 345-362. doi: 10.21608/bfsa.2023.223645.1827
Hussein, M., Mandour, M., AbdElghaffar Nasr, S., Meki, A., Fakhry, M. ANTI-OBESITY ACTION OF GREEN TEA EXTRACT AND CURCUMIN: ROLE OF C1Q/TNF-RELATED PROTEIN-12 (CTRP-12) AND CASPASE-2.. EKB Journal Management System, 2024; 47(1): 345-362. doi: 10.21608/bfsa.2023.223645.1827

ANTI-OBESITY ACTION OF GREEN TEA EXTRACT AND CURCUMIN: ROLE OF C1Q/TNF-RELATED PROTEIN-12 (CTRP-12) AND CASPASE-2.

Bulletin of Pharmaceutical Sciences Assiut University
Article 24, Volume 47, Issue 1, June 2024, Page 345-362  XML PDF (1.85 MB)
Document Type: Original Article
DOI: 10.21608/bfsa.2023.223645.1827
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Authors
Mohamed Hussein1; Manal Mandour2; Sary AbdElghaffar Nasr3; Abdel-Raheim Meki2, 4; Michel E. Fakhry email 2
1Department of Biochemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt
2Department of Medical Biochemistry, Faculty of Medicine, Assiut University, Assiut, Egypt
3Department of Pathology, Faculty of Veterinary Medicine, Assiut University, Assiut, Egypt.
4Department of Biochemistry, Faculty of Pharmacy, Sphinx University, New Assiut, Egypt
Abstract
Background: The prevalence of obesity is increasing. It is regarded to be among of the world's biggest health issues and the primary factor in metabolic syndrome, a group of illnesses including hypertension, diabetes mellitus, and dyslipidemia. Many studies proved the efficacy of dietary polyphenols ascurcuminand green tea extractin ameliorating obesity and its correlated disorders.

Methods: Our work was the first to explore the impact of green tea extract and curcumin on the insulin-sensitizing anti-inflammatory adipokine C1q/ TNF-related protein-12 (CTRP-12)serum level measured by ELISA and expression of caspase-2 in white adipose tissue invivo measured by qRT-PCR.

Results: We found that both green tea extract and curcumin elevated serum CTRP-12 level. Moreover, they stimulated adipocytes apoptosis via increasing the expression of caspase-2 decreasing adiposity.

Conclusion: The current study concludes that green tea extract and curcumin have prophylactic effect against obesity and obesity-related disorders.



Keywords: high-fat diet, caspase-2, CTRP-12, green tea extract, curcumin.
Keywords
high-fat diet; caspase-2; CTRP-12; green tea extract; curcumin
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