PYRIDINE DERIVATIVES AS ANTICANCER AGENTS: FDA-APPROVED DRUGS AND PROMISING REPORTED COMPOUNDS
El-Zahabi, M., Yousef, R., Eissa, I., Elwan, A. (2023). PYRIDINE DERIVATIVES AS ANTICANCER AGENTS: FDA-APPROVED DRUGS AND PROMISING REPORTED COMPOUNDS. EKB Journal Management System, 68(2), 64-81. doi: 10.21608/ajps.2023.332167
Mohamed Ayman ALy El-Zahabi; Reda G Yousef; Ibrahim H Eissa; Alaa Elwan. "PYRIDINE DERIVATIVES AS ANTICANCER AGENTS: FDA-APPROVED DRUGS AND PROMISING REPORTED COMPOUNDS". EKB Journal Management System, 68, 2, 2023, 64-81. doi: 10.21608/ajps.2023.332167
El-Zahabi, M., Yousef, R., Eissa, I., Elwan, A. (2023). 'PYRIDINE DERIVATIVES AS ANTICANCER AGENTS: FDA-APPROVED DRUGS AND PROMISING REPORTED COMPOUNDS', EKB Journal Management System, 68(2), pp. 64-81. doi: 10.21608/ajps.2023.332167
El-Zahabi, M., Yousef, R., Eissa, I., Elwan, A. PYRIDINE DERIVATIVES AS ANTICANCER AGENTS: FDA-APPROVED DRUGS AND PROMISING REPORTED COMPOUNDS. EKB Journal Management System, 2023; 68(2): 64-81. doi: 10.21608/ajps.2023.332167

PYRIDINE DERIVATIVES AS ANTICANCER AGENTS: FDA-APPROVED DRUGS AND PROMISING REPORTED COMPOUNDS

Al-Azhar Journal of Pharmaceutical Sciences
Volume 68, Issue 2, September 2023, Page 64-81  XML PDF (602.62 K)
DOI: 10.21608/ajps.2023.332167
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Authors
Mohamed Ayman ALy El-Zahabi email orcid 1; Reda G Yousef2; Ibrahim H Eissa2; Alaa Elwan2
1Al Mockhaim Al Daem street, Nasr 6thdistrict, Cairo Egypt
2Department of Pharmaceutical Medicinal Chemistry & Drug Design, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo11884, Egypt.
Abstract
Pyridine derivatives are a family of heterocyclic nitrogenous compounds possessing many of applications in the discovery of  anticancer drug. This synthetic category serve as the potent class of compounds in the treatment of  many types of tumors as breast cancer, myeloid leukemia, pancreatic cancer, liver cancer. In this review, the recent results of the published studies about pyridine derivatives were reported. In addition, the most promising candidates in each work was focused mentioning it anticancer activity compared to the reference molecules. This work may serve as a collection of promising candidates for further design and synthesis of  anti-cancer agents.
Keywords
Pyridine derivative; Anti-cancer agents; Biological targets
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