Biochemical Studies in The Effect of Nitrite Ion in Pre-chlorinated Drinking Water in Sohag Governorate on Male Albino Rats and Treatment with Vitamin C
El-Sawi, N., Redwan, M., Mahfouz, M., Elkholy, M. (2024). Biochemical Studies in The Effect of Nitrite Ion in Pre-chlorinated Drinking Water in Sohag Governorate on Male Albino Rats and Treatment with Vitamin C. EKB Journal Management System, 9(2), 133-139. doi: 10.21608/sjsci.2023.227690.1112
Nagwa Mohammed El-Sawi; Mostafa Redwan; Metwally Kotb Mahfouz; Mohamed Eid Elkholy. "Biochemical Studies in The Effect of Nitrite Ion in Pre-chlorinated Drinking Water in Sohag Governorate on Male Albino Rats and Treatment with Vitamin C". EKB Journal Management System, 9, 2, 2024, 133-139. doi: 10.21608/sjsci.2023.227690.1112
El-Sawi, N., Redwan, M., Mahfouz, M., Elkholy, M. (2024). 'Biochemical Studies in The Effect of Nitrite Ion in Pre-chlorinated Drinking Water in Sohag Governorate on Male Albino Rats and Treatment with Vitamin C', EKB Journal Management System, 9(2), pp. 133-139. doi: 10.21608/sjsci.2023.227690.1112
El-Sawi, N., Redwan, M., Mahfouz, M., Elkholy, M. Biochemical Studies in The Effect of Nitrite Ion in Pre-chlorinated Drinking Water in Sohag Governorate on Male Albino Rats and Treatment with Vitamin C. EKB Journal Management System, 2024; 9(2): 133-139. doi: 10.21608/sjsci.2023.227690.1112

Biochemical Studies in The Effect of Nitrite Ion in Pre-chlorinated Drinking Water in Sohag Governorate on Male Albino Rats and Treatment with Vitamin C

Sohag Journal of Sciences
Volume 9, Issue 2, June 2024, Page 133-139  XML PDF (537.14 K)
Document Type: Regular Articles
DOI: 10.21608/sjsci.2023.227690.1112
View on SCiNiTO View on SCiNiTO
Authors
Nagwa Mohammed El-Sawi1; Mostafa Redwanorcid 2; Metwally Kotb Mahfouz3; Mohamed Eid Elkholy email 1
1Department of Chemistry, Faculty of Science, Sohag University, Sohag 82524, Egypt
2Department of Geology, Faculty of Science, Sohag University, Sohag 82524, Egypt
3Biochemistry Department, Agricultural Research Center, Sohag, Egypt
Abstract
The presence of nitrites in groundwater may be a sign of sewage pollution. Drinking water typically has nitrite concentrations below 0.1 mg L-1. To examine the effect of nitrites on the liver of male albino rats that were affected by nitrite dosages, and then to evaluate the ameliorative effect of vitamin C on the liver of male albino rats, this study intends to measure the nitrite concentrations in groundwater in Sohag governorate, Egypt. 60 albino adult male rats were placed into 4 groups, each group contains 15 animals: T1: standard nutrition (Control group), T2: Drinking water containing (>0.2 mg L-1 nitrite) group. T3: Sodium nitrite (300 mg/kg of body weight) group, T4: Sodium nitrite followed by vitamin C (300 mg/kg of body weight) daily for 3 months. At the end of the experiment, all rats were sacrificed to collect blood samples and then evaluated aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), albumin, total antioxidant capacity (TAC), and catalase, which showed a significant difference between animal groups especially elevation of hepatic parameters and decrease of antioxidant parameters in T3. The results of the biochemical analysis of the nitrite group and vitamin C group showed that there is a significant improvement in all parameters measured in the vitamin C group compared to the nitrites group.
Keywords
Drinking water; Nitrite ion; Rats; Vitamin C; Sohag governorate; Egypt
Statistics
Article View: 105
PDF Download: 70