BIOCHEMICAL TARGETS AFFECTED BY SUBLETHAL DOSES OF CYPERMETHRIN IN MICE | ||||
Egyptian Journal of Agricultural Research | ||||
Article 15, Volume 77, Issue 2, March 1999, Page 701-711 PDF (2.25 MB) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/ejar.1999.332478 | ||||
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Authors | ||||
KAWTHER EL-GENDY1; ABDEL-KHALEK H. EL-SEBAE1; NAGAT ALY2; EIMAN RASHWAAN3 | ||||
1Department of Pesticide Chemistry, Faculty of agriculture, Alexandria University, Egypt | ||||
2Central Agricultural Pesticides Laboratory, Agricultural Research Centre, Dokki, Egypt | ||||
3Medical Research Institute, Alexandria University, Egypt | ||||
Abstract | ||||
The effects of repeated sublethal doses of cypermethrin (0.25 mg/Kg/day) for 14 days on some haematological, biochemical and immunological parameters in male mice were investigated 1 hour, 24 hours, 1,3 and 5 weeks after the last dose. No significant changes were recorded in hemoglobin content (1-1b), haematccrit value (Hct) and red blood cells count (BBC's). Only white blood cells count (WBC's) significantly increased 3 and 5 weeks after the last dose. The activities of the tested enzymes; adenosine triphosphatase (ATPase), carboxyfesterase (CaE), glutathione 5-transferase (GST), acid phosphatase (AcP), alkaline phosphatase (Alp), alanine transaminase (AIT) and aspartate transaminase (AsT) in treated choshen organs of male mice were increased gradually. Cypermethrin caused a pronounced direct suppressive effect on cellular immunity as illustrated by lymphocyte proliferation to mitogens and phagocytic activity. Also, humoral immunity as indicated by plaque forming cells (PFC) and haemagglutinating titre were suppressed. The suppressive effect of cypermethrin on immune response was time dependent. | ||||
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