Complications of Growth Hormone administration in Poor Ovarian Reserve undergoing ICSI. A Randomized Control study
Metawie, O., Younis, M., Elrefaie, W., Anany, H. (2024). Complications of Growth Hormone administration in Poor Ovarian Reserve undergoing ICSI. A Randomized Control study. EKB Journal Management System, 16(16), 23-28. doi: 10.21608/muj.2023.258185.1159
Ola Mohamed Metawie; Mohamed Hafez Younis; Waleed Elsayed Elrefaie; Hesham Anany. "Complications of Growth Hormone administration in Poor Ovarian Reserve undergoing ICSI. A Randomized Control study". EKB Journal Management System, 16, 16, 2024, 23-28. doi: 10.21608/muj.2023.258185.1159
Metawie, O., Younis, M., Elrefaie, W., Anany, H. (2024). 'Complications of Growth Hormone administration in Poor Ovarian Reserve undergoing ICSI. A Randomized Control study', EKB Journal Management System, 16(16), pp. 23-28. doi: 10.21608/muj.2023.258185.1159
Metawie, O., Younis, M., Elrefaie, W., Anany, H. Complications of Growth Hormone administration in Poor Ovarian Reserve undergoing ICSI. A Randomized Control study. EKB Journal Management System, 2024; 16(16): 23-28. doi: 10.21608/muj.2023.258185.1159

Complications of Growth Hormone administration in Poor Ovarian Reserve undergoing ICSI. A Randomized Control study

Medicine Updates
Volume 16, Issue 16, January 2024, Pages 23-28    PDF (1.12 M)
Document Type: Original Article
DOI: 10.21608/muj.2023.258185.1159
Authors
Ola Mohamed Metawie* 1; Mohamed Hafez Younis2; Waleed Elsayed Elrefaie3; Hesham Anany4
1Department of Obstetrics and Gynecology,
2Department Of Obstetrics and Gynecology, Portsaid University
3Department of Obstetrics and Gynecology, Port Said University
4Department of Obstetrics and Gynecology, Cairo University
Abstract
Introduction

Poor ovarian reserve (POR) is considered a serious condition that affects couples. There are different medical modalities and intervention trying to overcome POR. GH adjuvant therapy to ART is considered a promising drug. However, GH complications are not well studied.

Methods

Between 2021 to 2022. A prospective randomized control study, in which patients were divided into two groups, a study and a control group. Study group will receive an ICSI cycle with GH supplementation and control group.
Results
37 patients per group were included. Their mean age was 29.74± 5.88 years. The mean duration of infertility is also similar between the GH group (4.81 ± 2.16) and the control group (4.73 ± 2) with no significant difference between the groups (p = 0.86721). The average systolic blood pressure for the study group and the control group were 113 ± 20 ( 88 -135) and 110 ± 22 ( 87-130) mmHg respectively with no statistical significant difference ( p = 0.7412). The average random blood sugar mg/dl for the study group and the control group were 123±20 (90-140) and 119 ±24 ( 87-138) with no statistical significant different ( P= 0.6539). (Table 2) There were no cases with leg edema, added pain or change in overall features.

Conclusion
GH may have a positive role in POR undergoing ovarian stimulation. In addition, no sinister side effects of GH have been reported.
Keywords
GH; Complications; POR; infertility
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