The Effects of Growth Hormone Administration on ICSI Outcomes in Poor Ovarian Reserve. A Randomized Control Study
Metawie, O., Younis, M., Elrefaie, W., Al-Inany, H. (2024). The Effects of Growth Hormone Administration on ICSI Outcomes in Poor Ovarian Reserve. A Randomized Control Study. EKB Journal Management System, 16(16), 29-52. doi: 10.21608/muj.2023.257711.1158
Ola Mohamed Metawie; Mohamed Hafez Younis; Waleed Elsayed Elrefaie; Hesham Al-Inany. "The Effects of Growth Hormone Administration on ICSI Outcomes in Poor Ovarian Reserve. A Randomized Control Study". EKB Journal Management System, 16, 16, 2024, 29-52. doi: 10.21608/muj.2023.257711.1158
Metawie, O., Younis, M., Elrefaie, W., Al-Inany, H. (2024). 'The Effects of Growth Hormone Administration on ICSI Outcomes in Poor Ovarian Reserve. A Randomized Control Study', EKB Journal Management System, 16(16), pp. 29-52. doi: 10.21608/muj.2023.257711.1158
Metawie, O., Younis, M., Elrefaie, W., Al-Inany, H. The Effects of Growth Hormone Administration on ICSI Outcomes in Poor Ovarian Reserve. A Randomized Control Study. EKB Journal Management System, 2024; 16(16): 29-52. doi: 10.21608/muj.2023.257711.1158

The Effects of Growth Hormone Administration on ICSI Outcomes in Poor Ovarian Reserve. A Randomized Control Study

Medicine Updates
Volume 16, Issue 16, January 2024, Page 29-52  XML PDF (1.73 MB)
Document Type: Original Article
DOI: 10.21608/muj.2023.257711.1158
View on SCiNiTO View on SCiNiTO
Authors
Ola Mohamed Metawie email orcid 1; Mohamed Hafez Younis2; Waleed Elsayed Elrefaie3; Hesham Al-Inany4
1Obstetrics and Gynecology Department, ,
2Obstetrics and Gynecology Department, Portsaid University
3Obstetrics and Gynecology Department, Port Said University
4Obstetrics and Gynecology Department, Cairo University
Abstract
Introduction
The incidence of POR ranges from 9 to 24%. GH is a peptide produced from the pituitary gland. Growth hormone leads to the formation of IGF-1. GH and IGF-1 are both important in the formation of steroid hormones in the ovary.
Methods
Between 2021 to 2022, a randomized control study, in which patients were divided into, a study and a control group. Study group will receive an ICSI cycle with GH and control group will only receive ICSI.
Results
The mean AMH level and AFC are similar between the GH group (0.6 ± 0.22 ng/ml) and (5.73 ± 1.88) and the control group (0.61 ± 0.22 ng/ml) and (5.76 ± 1.72). The mean E2 level is significantly higher in the GH group than in the control group. Similarly, there is no significant difference in the mean number of mature follicles between the GH group and the control group. The mean number of stimulation days for the GH group (9.84 ± 0.69) is significantly lower than that of the control group (11.11 ± 0.74). The mean HMG dose for the GH group (4427.03 ± 309.48) is significantly lower than that of the control group (4998.65 ± 331.76). Out of the 37 patients in the GH group, 11 (29.73%) achieved pregnancy, while in the control group, 7 (18.92%)
Conclusion
The role of GH as an adjunct in ARTs in POR women favors the increase of E2 levels on the HCG day and decreases the duration of stimulation and the gonadotropins dose.
Keywords
Infertility; GH; AMH; AFC; Oocyte
Statistics
Article View: 55
PDF Download: 43