Validity of Systemic Inflammatory Markers as Predictors of Severity and Extent of Mucosal Inflammation in Ulcerative Colitis
Abdelmaksoud, M., Abdelmonem, A., Jouda, A., Atwa, H., Elkhashab, M. (2023). Validity of Systemic Inflammatory Markers as Predictors of Severity and Extent of Mucosal Inflammation in Ulcerative Colitis. EKB Journal Management System, (), -. doi: 10.21608/zumj.2023.252179.3026
Mona Ahmed Abdelmaksoud; Ali Refaat Abdelmonem; Amal A Jouda; Hanaa A Atwa; Mohamed N Elkhashab. "Validity of Systemic Inflammatory Markers as Predictors of Severity and Extent of Mucosal Inflammation in Ulcerative Colitis". EKB Journal Management System, , , 2023, -. doi: 10.21608/zumj.2023.252179.3026
Abdelmaksoud, M., Abdelmonem, A., Jouda, A., Atwa, H., Elkhashab, M. (2023). 'Validity of Systemic Inflammatory Markers as Predictors of Severity and Extent of Mucosal Inflammation in Ulcerative Colitis', EKB Journal Management System, (), pp. -. doi: 10.21608/zumj.2023.252179.3026
Abdelmaksoud, M., Abdelmonem, A., Jouda, A., Atwa, H., Elkhashab, M. Validity of Systemic Inflammatory Markers as Predictors of Severity and Extent of Mucosal Inflammation in Ulcerative Colitis. EKB Journal Management System, 2023; (): -. doi: 10.21608/zumj.2023.252179.3026

Validity of Systemic Inflammatory Markers as Predictors of Severity and Extent of Mucosal Inflammation in Ulcerative Colitis

Zagazig University Medical Journal
Articles in Press, Accepted Manuscript, Available Online from 27 December 2023  XML
Document Type: Original Article
DOI: 10.21608/zumj.2023.252179.3026
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Authors
Mona Ahmed Abdelmaksoud email orcid 1; Ali Refaat Abdelmonem2; Amal A Jouda3; Hanaa A Atwaorcid 4; Mohamed N Elkhashab5
1Zagazig University Hospitals
21 M.B; B.Ch.; Faculty of Medicine, Zagazig University,Zagazig,Egypt
3Assistant Professor of Tropical Medicine, Faculty of Medicine, Zagazig University, Zagazig,Egypt
4zagazig university
5Professor of Tropical Medicine, Faculty of Medicine, Zagazig University ,Zagazig,Egypt
Abstract
Background: The inflammatory process in the colonic mucosa among ulcerative colitis (UC) patients could be reflected as systemic inflammatory response with subsequent elevation of the various inflammatory biomarkers. We aimed at this research to evaluate the role of systemic inflammatory mediators; erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), serum albumin level, total leucocytic count, leucocyte/platelet ratio and mean platelet volume (MPV) as predictors of the severity of mucosal inflammation in patient with ulcerative colitis.

Methods: Our cross-sectional study included 30 cases diagnosed with ulcerative colitis in different stages of the disease. Estimation of serum ESR, CRP, TLC levels were done for all participants.

Results: After applying regression analysis, both WBCs count, and fecal calprotectin were significant predictors of disease activity. CRP and WBC/ platelet ratio were significantly correlated to Mayo score of the patients (p= 0.001, 0.007 respectively). Sensitivity of CRP (>15) ESR (>19.5), WBCs count (>8500), WBCs/ platelet ratio (>0.029), , MPV (>8.75 f/L) serum albumin level (>4.15 gm) as a predictors of disease activity were 90.8%, 81.8%,90.9%, 72.7%, 54.5% and 63.6%, respectively with the ability to exclude 81.3%, 73.5%,85.2%,78.9%, 53.1%and 57.3%, of negative cases respectively and accuracy of 86.7%,76.7%,, 86.7%, 76.7%,53.3%,60.0%, respectively.

Conclusions: The levels of CRP, white blood cell count, leukocyte/platelet ratio, and fecal calprotectin were significantly greater in individuals with active UC compared to those in remission. CRP, WBCs count, leukocyte/platelet ratio and fecal calprotectin may be utilized as useful indexes to assess the activity and severity of UC.
Keywords
Systemic Inflammatory Markers; Predictors; Mucosal Inflammation; Ulcerative Colitis
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