Predictive value of trefoil factor 3 for identifying activity in ulcerative colitis patients: a comparison with fecal calprotectin and C-reactive protein
Khairallah, A., El-Fayoumy, M., El-Sherbiny, A., El-shorbagy, M., El-ghamry, F. (2023). Predictive value of trefoil factor 3 for identifying activity in ulcerative colitis patients: a comparison with fecal calprotectin and C-reactive protein. EKB Journal Management System, 4(2), 109-118. doi: 10.21608/jram.2023.206430.1209
Ahmed A. Khairallah; Mohammed S. El-Fayoumy; Ashraf A. El-Sherbiny; Mohammed S. El-shorbagy; Fathy A. El-ghamry. "Predictive value of trefoil factor 3 for identifying activity in ulcerative colitis patients: a comparison with fecal calprotectin and C-reactive protein". EKB Journal Management System, 4, 2, 2023, 109-118. doi: 10.21608/jram.2023.206430.1209
Khairallah, A., El-Fayoumy, M., El-Sherbiny, A., El-shorbagy, M., El-ghamry, F. (2023). 'Predictive value of trefoil factor 3 for identifying activity in ulcerative colitis patients: a comparison with fecal calprotectin and C-reactive protein', EKB Journal Management System, 4(2), pp. 109-118. doi: 10.21608/jram.2023.206430.1209
Khairallah, A., El-Fayoumy, M., El-Sherbiny, A., El-shorbagy, M., El-ghamry, F. Predictive value of trefoil factor 3 for identifying activity in ulcerative colitis patients: a comparison with fecal calprotectin and C-reactive protein. EKB Journal Management System, 2023; 4(2): 109-118. doi: 10.21608/jram.2023.206430.1209

Predictive value of trefoil factor 3 for identifying activity in ulcerative colitis patients: a comparison with fecal calprotectin and C-reactive protein

Journal of Recent Advances in Medicine
Volume 4, Issue 2, July 2023, Page 109-118  XML PDF (934.72 K)
Document Type: Original Article
DOI: 10.21608/jram.2023.206430.1209
View on SCiNiTO View on SCiNiTO
Authors
Ahmed A. Khairallah email orcid 1; Mohammed S. El-Fayoumy2; Ashraf A. El-Sherbiny1; Mohammed S. El-shorbagy3; Fathy A. El-ghamry2
1Internal Medicine Department, National Research Centre, Cairo, Egypt.
2Internal Medicine Department, Faculty of Medicine for Boys, Cairo, Al-Azhar University, Egypt.
3Clinical Pathology Department, Faculty of Medicine for Boys, Cairo, Al-Azhar University, Egypt.
Abstract
Background: Trefoil factor-3 (TFF3) is primarily expressed by small intestine and colon goblet cells. Several studies have revealed that it plays a crucial function in mucosal protection and gastrointestinal tract repair.
Objective: to evaluate the significance of TFF3 as a marker of disease activity in ulcerative colitis (UC) patients.
Methods: A hospital-based case control study was done on 40 active-UC patients, 40 patients in remission state who underwent colonoscopy and 40 non-ulcerative colitis healthy individuals as control group. Serum TFF3 was measured by ELISA and compared to C-reactive protein (CRP) and fecal calprotectin (FC) values. Clinical and endoscopic assessment was scored according to Lichtiger Index and ulcerative colitis endoscopic severity index (UCEIS).
Results: Serum TFF3 was significantly correlated with Lichtiger Index (r=0.671), UCEIS (r=0.642), FC (r=0.8048) and CRP (r=0.3759). Serum TFF3 cutoff point <4.25 ng/ml indicated remission with a specificity 69.2%, 69%; sensitivity 92%, 97% for endoscopic and clinical indices respectively. Also, TFF3 significantly differentiated between mild, moderate, and severe diseases. The AUC of TFF3+FC was significantly higher than that of TFF3 and FC alone for predicting UC remission.
Conclusion: Serum TFF3 is significantly correlated with clinical, endoscopic indices and FC in UC patients. Serum TFF3 is a powerful predictive biomarker of remission alone and in combination with FC in UC patients.
Keywords
Trefoil factor 3; fecal calprotectin; inflammatory bowel disease; CRP
Supplementary Files
Statistics
Article View: 49
PDF Download: 47