The Anti-Diabetic Effect of Rhopilema nomadica Jellyfish Natural Extracts in Streptozoticin-Induced Type-2 Diabetes Mellitus in Rats
El-Naggar, S., Salama, W., El-Desouki, N., Tabl, G., Abo Jobier, R., Abdelsattar, A. (2023). The Anti-Diabetic Effect of Rhopilema nomadica Jellyfish Natural Extracts in Streptozoticin-Induced Type-2 Diabetes Mellitus in Rats. EKB Journal Management System, 9(4), 392-410. doi: 10.21608/jbaar.2023.333006
Sabry A. El-Naggar; Wesam M. Salama; Nabila I. El-Desouki; Ghada A. Tabl; Rasha A. Abo Jobier; Amal M. Abdelsattar. "The Anti-Diabetic Effect of Rhopilema nomadica Jellyfish Natural Extracts in Streptozoticin-Induced Type-2 Diabetes Mellitus in Rats". EKB Journal Management System, 9, 4, 2023, 392-410. doi: 10.21608/jbaar.2023.333006
El-Naggar, S., Salama, W., El-Desouki, N., Tabl, G., Abo Jobier, R., Abdelsattar, A. (2023). 'The Anti-Diabetic Effect of Rhopilema nomadica Jellyfish Natural Extracts in Streptozoticin-Induced Type-2 Diabetes Mellitus in Rats', EKB Journal Management System, 9(4), pp. 392-410. doi: 10.21608/jbaar.2023.333006
El-Naggar, S., Salama, W., El-Desouki, N., Tabl, G., Abo Jobier, R., Abdelsattar, A. The Anti-Diabetic Effect of Rhopilema nomadica Jellyfish Natural Extracts in Streptozoticin-Induced Type-2 Diabetes Mellitus in Rats. EKB Journal Management System, 2023; 9(4): 392-410. doi: 10.21608/jbaar.2023.333006

The Anti-Diabetic Effect of Rhopilema nomadica Jellyfish Natural Extracts in Streptozoticin-Induced Type-2 Diabetes Mellitus in Rats

Journal of Bioscience and Applied Research
Volume 9, Issue 4, December 2023, Page 392-410  XML PDF (1.09 MB)
Document Type: Original Article
DOI: 10.21608/jbaar.2023.333006
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Authors
Sabry A. El-Naggar email 1; Wesam M. Salama email 1; Nabila I. El-Desouki1; Ghada A. Tabl1; Rasha A. Abo Jobier1; Amal M. Abdelsattar2
1Zoology Department, Faculty of Science, Tanta University, Egypt
2Anatomy &Embryology Department, Faculty of Medicine, Tanta University
Abstract
Globally, diabetes mellitus (DM) disease is one of the main causes of death. Type-2 diabetes mellitus (T2-DM) cannot be cured by first-line medications, and long-term use carries a significant risk of serious side effects. Novel antidiabetic agents with high efficacy are required. In the T2-DM rats’ model, the anti-diabetic effect of Rhopilema nomadica venom (RNV) and R. nomadica umbrellar extracts (RNUE) was assessed. Biometric and biochemical measurements were determined. The median lethal doses (LD50) of RNV and RNUE were estimated, and then Sprague Dawley male rats were split into five groups (n=10) as follows; group 1 (Gp1) served as a negative control. Gp2 to Gp5 were given a high-fat diet (HFD) and then, injected with STZ (30 mg/kg) interperitoneal (i.p.). Gp2 was kept as diabetic rats (T2-DM rats). Metformin (Met) (150 mg/kg), RNV (7.5 mg/kg), and RNUE (14.4 mg/kg) were given to Gp3, Gp4, and Gp5, respectively. All treatments were taken i.p., once every day for eight weeks body weight (b.wt) changes, the levels of glucose, C-peptide, biochemical parameters, and the histopathological alterations were assessed. R. nomadica diameter was 35- 40 cm, and its weight was 4- 4.5 kg. RNV and RNUE total antioxidant capacities were 2.39 ± 0.18 and 2.92 ± 0.26 mg/g. RNV and RNUE protein profiles showed eight and seven bands. Treatment of T2-DM rats with Met or RNUE led to a hypoglycemic effect as indicated by improvement of b.wt changes, glucose, C-peptide levels, hepato-renal function, antioxidant/oxidant biomarkers status, and insulin-secreting β-cells in the pancreatic islets.
Keywords
Anti-diabetic; Rhopilema nomadica; Type-2 diabetes mellitus; Umbrella extracts; Venom
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