Detection of Creatinine in Vaginal Fluid for Diagnosis of Preterm Premature Rupture of Membranes
El-Garhy, I., Sabry, N., Abdel-Gahfar, M., Ahmed, A. (2019). Detection of Creatinine in Vaginal Fluid for Diagnosis of Preterm Premature Rupture of Membranes. EKB Journal Management System, 75(5), 2894-2899. doi: 10.21608/ejhm.2019.33364
Ismail T. El-Garhy; Noha M. Sabry; Medhat A. Abdel-Gahfar; Ahmed A. Ahmed. "Detection of Creatinine in Vaginal Fluid for Diagnosis of Preterm Premature Rupture of Membranes". EKB Journal Management System, 75, 5, 2019, 2894-2899. doi: 10.21608/ejhm.2019.33364
El-Garhy, I., Sabry, N., Abdel-Gahfar, M., Ahmed, A. (2019). 'Detection of Creatinine in Vaginal Fluid for Diagnosis of Preterm Premature Rupture of Membranes', EKB Journal Management System, 75(5), pp. 2894-2899. doi: 10.21608/ejhm.2019.33364
El-Garhy, I., Sabry, N., Abdel-Gahfar, M., Ahmed, A. Detection of Creatinine in Vaginal Fluid for Diagnosis of Preterm Premature Rupture of Membranes. EKB Journal Management System, 2019; 75(5): 2894-2899. doi: 10.21608/ejhm.2019.33364

Detection of Creatinine in Vaginal Fluid for Diagnosis of Preterm Premature Rupture of Membranes

The Egyptian Journal of Hospital Medicine
Article 23, Volume 75, Issue 5, April 2019, Page 2894-2899  XML PDF (319.39 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2019.33364
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Authors
Ismail T. El-Garhy1; Noha M. Sabry1; Medhat A. Abdel-Gahfar2; Ahmed A. Ahmed email 1
1Department of Obstetrics and Gynecology, Faculty of Medicine – Al-Azhar University
2Department of Clinical Pathology, Faculty of Medicine – Al-Azhar University
Abstract
Background: to evaluate the role of vaginal fluid creatinine level in diagnosis of preterm prelabour rupture of membranes among patients giving history of amniotic fluid leak. Objectives: the aim of this study was to evaluate the reliability of vaginal fluid creatinine level in the vaginal fluid for diagnosis of prelabour premature rupture of membranes. Patients and Methods: 100 pregnant women with gestational age 24: 37 weeks gestation participated in the present study divided into 2 groups. Group I (confirmed PROM group) & group II (control non-PROM group). All patients underwent a sterile speculum examination for detection of amniotic fluid pooling in the posterior vaginal fornix followed by taking 3ml from vaginal fluid. Creatinine measurement was done using ELISA. Results: The mean creatinine levels in vaginal fluid in group (I) & group (II) were.70 ± 0.88 and.04 ± 0.18 mIU/mL respectively. The difference was statistically significant (P value < 0.001). With creatinine cut-off value of 0.25 mIU/ml, the sensitivity & specificity in confirming PROM were 72 and 94% respectively. Conclusion: Creatinine level was significantly higher in pregnant women with definite PROM. Therefore, vaginal fluid creatinine can be used as an easy, rapid, reliable and non-invasive test for confirming the diagnosis of PROM and can be used as an adjunctive test in equivocal cases.
Keywords
creatinine; preterm prelabour rupture of membranes
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