Study of Serum Immunoglobulins G and M Levels in Children with Down Syndrome and Their Relation with Recurrent Lower Respiratory Tract Infection | ||||
The Egyptian Journal of Hospital Medicine | ||||
Article 24, Volume 75, Issue 5, April 2019, Page 2900-2907 PDF (349.96 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/ejhm.2019.33365 | ||||
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Authors | ||||
Manar Emad Aldeen Ghazy ![]() | ||||
1Department of Pediatric Medicine, Faculty of Medicine, Tanta University, Egypt | ||||
2Department of Clinical Pathology, Faculty of Medicine, Tanta University, Egypt | ||||
Abstract | ||||
Background: Children with Down syndrome appear to be more likely susceptible to respiratory tract infections and it is an important cause of morbidity and mortality among them. Aim of the study: It was to investigate the relationship between levels of IgG and IgM in Down syndrome and recurrent lower respiratory tract infections. Subjects and Methods: This study was conducted on 40 children who were categorized into 2 groups: patient group, which includes children with Down syndrome patients presented with LRTIs, their karyotyping revealed trisomy 21 in all cases and their age range from 1 to 13 years. Control group, which includes 20 healthy children matched for sex and age with patient group. They were subjected to full history taking & thorough clinical examination, and they investigated for complete blood picture, C-reactive protein and serum immunoglobulins (IgG & IgM) using ELISA technique. Results: Plasma levels of immunoglobulin G (IgG) were elevated in Down syndrome with significant increase the frequency of lower respiratory tract infections and hospital admission. Plasma levels of immunoglobulin M (IgM) were decrease in down patients with significant increase in the frequency of lower respiratory tract infections and hospital admission. Conclusion: These findings suggest the importance of estimation and follow up of serum levels of IgG &Ig M in cases of Ds with recurrent respiratory tract infections. | ||||
Keywords | ||||
immunoglobulins; Down syndrome; Recurrent Lower Respiratory Tract Infection | ||||
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