A pilot study of The Efficacy of Using Chromium Salts in Reducing Hirsutism Scoring & BMI in Polycystic Ovary Syndrome Patients: Double Blinded Randomized Controlled Trial | ||||
| The Egyptian Journal of Fertility of Sterility | ||||
| Article 10, Volume 27, Issue 6 - Serial Number 11106352, November 2023, Page 79-88 PDF (2.81 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/egyfs.2023.333782 | ||||
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| Authors | ||||
Dina Yahia Aly Mansour1; Heba Mohammed Eid2; Marwa Saber Snosi   3, 4, 5
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| 1Department of Obstetrics & Gynecology, Ain Shams University ,Cairo, Egypt | ||||
| 2Department of Obstetrics & Gynecology Sharq El Madina Hospital Alexandria, Egypt. | ||||
| 3Lecturer of obstetrics and gynecology Faculty of medicine, Ain Shams University, Cairo, Egypt | ||||
| 4Consultant of obstetrics and gynecology Almaaly Hospital | ||||
| 5Department of Obstetrics & Gynecology,Al Maaly Hospital ,Hafr El batin,Kingdom Of Saudia Arabia. | ||||
| Abstract | ||||
| Background: Polycystic ovary syndrome (PCOS) is one of the most frequent endocrinopathies in women in reproductive age. the clinical image of the disease is heterogeneous. Hirsutism is one of the gynecological symptoms of PCOS with prevalence ranging from 70-80% in affected cases. Objective: To assess the effect of chromium salts in addition to metformin on hirsutism scoring and Body Mass Index in polycystic ovary syndrome patients. Methods: This double blinded randomized controlled trial at Ain Shams University Maternity Hospital included sixty cases of PCOS complaining of hirsutism, age between 18 and 40 years were included, while Patients known to be diabetic, hypertensive, receiving corticosteroids, psychotropic drugs, diuretics, Ovulation induction drugs, known hypersensitivity or contraindications to the used medications or those who used permanent methods of hair removal were excluded. . The patients were randomly divided into two equal groups. Group S were thirty cases who received metformin and chromium picolinate and Group C were thirty cases receiving metformin and placebo in the form of vitamin C retard. Results: There was a highly statistically significant difference between two groups as regard weight loss, BMI, hirsutism score and menstrual regularity in favor to intervention group after 4 months follow up as p- value was <0.001. There was No significant difference between two groups as regard side effects reported about the drugs as p-value was >0.05. Conclusion: Adding chromium picolinate to metformin in PCOS patients caused further improvement of Hirsutism score and regularity of menses, and further decrease in BMI. | ||||
| Keywords | ||||
| Keywords: Polcystic ovaries; hirsutism; chromium | ||||
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