The role of vitamin D in determining Intra-cytoplasmic sperm injection outcome: A Quasi-experimental study | ||||
| Journal of Reproductive Medicine and Embryology | ||||
| Article 7, Volume 1, Issue 1, January 2024, Page 42-47 PDF (273.53 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jrme.2024.258978.1000 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Ismail Elfortia; Awatif Andisha; Hanan Eljabu  ; Asma Zablah
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| Assisted Reproductive Technique Unit, Libyan National Fertility Center, Qassar Ahmed, residential city, Misurata, Libya. | ||||
| Abstract | ||||
| Background: The optimization of clinical pregnancy rates following assisted reproductive technologies relies on various factors, including embryo quality and the implantation process. Recent research has focused on the role of vitamin D in enhancing implantation during intracytoplasmic Sperm Injection (ICSI). Objective: The primary objective of this study was to investigate the impact of vitamin D level on implantation, with secondary objectives examining the associations between vitamin D levels and clinical pregnancy rates and live birth rates. Materials and Methods: A quasi-experimental study was conducted at the Libyan National Fertility Centre and involved 60 infertile women. Each participant underwent two ICSI cycles, with the first cycle using insufficient vitamin D levels and the second using sufficient vitamin D levels. Excluded patients due to polycystic ovaries, endometriosis, premature ovarian failure, and male factor infertility. The Endocrine Society defined vitamin D insufficiency as levels <20 ng/ml. Results: Patients were assessed at two phases based on vitamin D levels—insufficient and sufficient phase. Clinical pregnancy rates were 31.67% and 61.67%, respectively (p<.016). The endometrial configuration, including thickness and pattern, positively correlated with sufficient vitamin D levels (p<.027). However, no statistically significant difference in oocyte quality was observed. Conclusion: The findings of this study affirm that vitamin D levels have a positive predictive value for ICSI outcomes. This study recommends vitamin D supplementation among infertile patients to enhance CPR and LBR. | ||||
| Keywords | ||||
| vitamin D; infertile; clinical pregnancy; live birth rates; intracytoplasmic sperm injection | ||||
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