Analysis of Dose Distribution in Patients with Breast Cancer Treated with Adjuvant Rapid Arc versus Conventional Radiotherapy | ||||
| SECI Oncology Journal | ||||
| Volume 11, Issue 4, October 2023, Page 352-356 | ||||
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| Abstract | ||||
| Background: Breast cancer is one of the most prevalent cancers among women. The objective of this research is to compare adjuvant Rapid Arc radiotherapy with conventional modality in respect of dose distribution in target volume and critical organs in patients with breast cancer post-surgery. Patients and Methods: This prospective research enrolled 98 cases diagnosed with primary breast cancer post conservative or mastectomy surgery recruited from Clinical Oncology Department, Zagazig University and International Medical Center, Egypt between January 2021-December 2022. They were categorized into 2 groups; group A underwent therapy by 3D-Conformal Radiotherapy (3DCRT) whereas group B was managed by Rapid Arc radiotherapy (RA). Both groups received 50 Gy in 25 fractions. Results: Each group had 49 patients. Both plans achieved similar target coverage; however RA had significantly increasing in minimum dose to the target more than 3D (66.21% vs 28.86%, p=0.001), moreover the Homogeneity Index (HI) & Conformity Index (CI) of RA were better than 3D-CRT (HI 1.05 vs 1.2, p=0.08 and CI 0.76 vs 0.38, p=0.034). Both plans had comparable results regarding to mean heart dose, V25 of heart, mean lung dose, V20 of ipsilateral lung and contralateral lung dose, however; 3D-CRT had better sparing in case of V5 & V10 of heart, V10 of ipsilateral lung and contralateral breast dose. Conclusion: Both RA & 3D-CRT have similar target coverage; however RA had better CI & HI at the expense of organs at risk sparing so RA may be used in sophisticated cases for whom optimal target coverage cannot be achieved by 3D-CRT. | ||||
| Keywords | ||||
| breast; Rapid arc; conventional radiotherapy | ||||
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