Serum Level of Interleukin 6 in Children with Febrile Seizures | ||||
| International Journal of Medical Arts | ||||
| Article 12, Volume 5, Issue 11, November 2023, Page 3875-3880 PDF (938.46 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ijma.2023.183612.1581 | ||||
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| Authors | ||||
Mohamed Ismail Ahmed  1; Ahmed Helal Elsayed2; Mahmoud Mohamed Abd-Elmotalp2; Medhat Ali Salah3
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| 1Department of Pediatrics, Al-hayat Portfoad Hospital, Ministry of Health, Port Said, Egypt | ||||
| 2Department of Pediatrics, Faculty of Medicine, Al-Azhar University, Cairo, Egypt | ||||
| 3Department of Clinical Pathology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt | ||||
| Abstract | ||||
| Background: Febrile seizures [FSs] are frequently observed seizure occurrences during childhood, making them the most prevalent form of seizures in this age group. The activation of the cytokine network is known to play a substantial role in the development of febrile seizures. It is hypothesized that the activation and subsequent release of Interleukin [IL]-6 may be responsible for the induction of fever in individuals experiencing febrile seizures. Interleukin-6 [IL-6] is widely recognized as a pivotal cytokine in the pathogenesis of febrile seizures. The Aim of the work: This study aims to assess the value of serum interleukin-6 [IL-6] in children with febrile seizures [simple or complex]. Patients and Methods: This cross-sectional controlled study was conducted on 100 children, 50 formed the febrile seizure group [35 patients had a simple febrile seizure and 15 had a complex febrile seizure] aged 6 months to 6 years and 50 matched febrile children formed the control group. The patients of both groups were selected in the period from February to September 2022. Results: We compared the serum IL-6 between the studied groups. The mean level of IL-6 in simple febrile seizure [SFS] was 44.04 ± 39.4, in complex febrile seizure [CFS] was 124.4 ± 95.69 and in the control group, it was 16.98 ± 14.4. Serum IL-6 was significantly higher in complex febrile seizure than in simple febrile seizure and the control group. Conclusion: Inflammatory cytokines especially IL-6 play an important role in the genesis of febrile seizures. | ||||
| Keywords | ||||
| Febrile Seizures; Interleukin-6; Simple febrile seizure; Complex febrile seizure | ||||
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