Measurement of C-Peptide Level in The Umbilical Cord of Infants of Diabetic Mothers and Its Relationship to The Risk of Hypoglycemia
Abo Amer, A., Asar, E., Rashwan, M., Ali, A. (2024). Measurement of C-Peptide Level in The Umbilical Cord of Infants of Diabetic Mothers and Its Relationship to The Risk of Hypoglycemia. EKB Journal Management System, 41(1), 34-42. doi: 10.21608/bmfj.2023.253583.1972
Alrawhaa Abo Amer; Effat Hussein Asar; Maha Tahir Rashwan; Asmaa Aidy Ali. "Measurement of C-Peptide Level in The Umbilical Cord of Infants of Diabetic Mothers and Its Relationship to The Risk of Hypoglycemia". EKB Journal Management System, 41, 1, 2024, 34-42. doi: 10.21608/bmfj.2023.253583.1972
Abo Amer, A., Asar, E., Rashwan, M., Ali, A. (2024). 'Measurement of C-Peptide Level in The Umbilical Cord of Infants of Diabetic Mothers and Its Relationship to The Risk of Hypoglycemia', EKB Journal Management System, 41(1), pp. 34-42. doi: 10.21608/bmfj.2023.253583.1972
Abo Amer, A., Asar, E., Rashwan, M., Ali, A. Measurement of C-Peptide Level in The Umbilical Cord of Infants of Diabetic Mothers and Its Relationship to The Risk of Hypoglycemia. EKB Journal Management System, 2024; 41(1): 34-42. doi: 10.21608/bmfj.2023.253583.1972

Measurement of C-Peptide Level in The Umbilical Cord of Infants of Diabetic Mothers and Its Relationship to The Risk of Hypoglycemia

Benha Medical Journal
Article 4, Volume 41, Issue 1, March and April 2024, Page 34-42  XML PDF (662.5 K)
Document Type: Original Article
DOI: 10.21608/bmfj.2023.253583.1972
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Authors
Alrawhaa Abo Amer1; Effat Hussein Asar2; Maha Tahir Rashwan3; Asmaa Aidy Ali email 4
1Professor of Pediatrics, Faculty of Medicine, Benha University
2Assistant Professor of Pediatrics, Faculty of Medicine, Benha University
3Lecturer of Clinical Pathology, Faculty of Medicine, Benha University
4(M.B.B.Ch, Faculty of Medicine, Al-Azhar University)
Abstract
Background: Infants born to diabetic mothers face an increased risk of hypoglycemia, necessitating reliable predictive markers for early intervention. This study aimed to measure C-Peptide in umbilical cord blood, to determine whether it can be used as a predictor of hypoglycemia in infants of diabetic mothers. Methods: A total of 50 infants born to diabetic mothers were studied, with 25 experiencing hypoglycemia and 25 remaining normoglycemic. Detailed histories, comprehensive examinations, and multi-level investigations were conducted, including C-peptide measurement from umbilical cord blood and monitoring of glucose levels postnatally. Results: In the hypoglycemic group, mean cord C-peptide levels were significantly higher (5.2 ± 0.55 ng/ml) compared to the normoglycemic group (1.71 ± 0.62 ng/ml). A significant negative correlation was found between cord C-peptide levels and the incidence of hypoglycemia. Additionally, a positive correlation existed between cord C-peptide levels and birth weight. The sensitivity of cord C-peptide in predicting hypoglycemia was 90%, with a specificity of 88% and a cut-off value of 4.2. Conclusion: Cord C-peptide levels in infants of diabetic mothers show promise as a predictive biomarker for hypoglycemia, demonstrating high sensitivity and specificity.
Keywords
Infants; Diabetic mothers; Cord C-peptide; Hypoglycemia; Predictive marker
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