Ameliorative Effects of Methanolic extract of Erythrina variegate in Scopolamine-Induced Amnesic in Adult Zebrafish (Daniorerio) Model | ||||
| Egyptian Journal of Aquatic Biology and Fisheries | ||||
| Article 65, Volume 27, Issue 6, November and December 2023, Page 1131-1140 PDF (436.24 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejabf.2023.334657 | ||||
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| Author | ||||
| Saleem Ahmed et al. | ||||
| Abstract | ||||
| Erythrina variegate (EV) possesses a wide range of biological activities, including-anticancer,-antidiabetic, hepatoprotective, -antirheumatic, antibacterial, and antiviral properties. Methanolic extract of Erythrina variegate (MetEEV) has not been studied for its neuroprotective properties. The purpose of this study was to look into the effect of MetEEV-on-scopolamine (Sco)-induced anxiety, amnesia, and brain oxidative stress in zebrafish, in addition to figuring out the underlying mechanism. The zebrafish were given MetEEV (260, 520, and 780g/ L) for seven days in a row before being given Sco (100μM) for 30 minutes before the behavioral tests (locomotor activity and cognitive function). The in-vivo antioxidant status and Acetylcholinesterase- (AChE) -activity were also -evaluated for the further assessment of possible mechanisms of MetEEV in enhancing memory capacities in zebrafish. MetEEV-could-improve-memory-and-reduce-brain oxidative stress in sco-induced zebrafish, as well as regulating cholinergic function by inhibiting AChE activity. Our findings suggest that MetEEV could be a promising candidate compound for treating amnesia by restoring cholinergic activity and alleviating brain oxidative stress. | ||||
| Keywords | ||||
| Erythrina variegate; Alzheimer’s disease; Zebrafish; Acetylcholinesterase; Oxidative stress | ||||
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