Immunohistochemical Expression of SIX1 in Papillary Thyroid Carcinoma | ||||
| Minia Journal of Medical Research | ||||
| Articles in Press, Accepted Manuscript, Available Online from 08 January 2024 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mjmr.2024.259835.1591 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Aya Fathy Yehia  1; Mariana Gayyed2; Azza Mohamed Abdel Zaher3
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| 1Pathology faculty of medicine minia university | ||||
| 236 Moustafa Fahmy street | ||||
| 3Pathology department, Faculty of Medicine, Minya University, Egypt | ||||
| Abstract | ||||
| Abstract: Background: Thyroid cancer (TC) is the most common type of malignant endocrine cancer and it's ranked as the 10th most common cancer worldwide, and its incidence increases, due to improvement of diagnostic procedures. Papillary thyroid cancer (PTC) is the most frequent type of differentiated thyroid carcinoma. In Egypt PTC subtype represents 85% of all TC cases. SIX1 is expressed in a wide range of normal and neoplastic tissues and it has different pathways in tumorigenesis in different tissues. SIX1 is upregulated in human thyroid cancer cell and promoted cell proliferation and invasion. Aim of the work: this study was conducted to research the association between SIX1 expression and the clinicopathological features of PTC. Material and Methods: Immunohistochemical staining of SIX1 was conducted on 50 randomly chosen tissue specimens of PTC 34 (68%) were classic PTC and 16 (32%) were follicular subtype, that was done by using the avidin biotin-peroxidase complex method with diaminobenizidine (DAB) chromogen detection system. Results: High SIX1 expression was detected in 36% of cases. SIX1 expression showed statistically significant correlation with tumor focality (P= 0.003), lymph node metastasis (P= 0.002), tumor grade (P= 0.002), advanced tumor stage (P= 0.01) assessed by pT staging system, tumor necrosis (P= 0.002), lymphovascular, perineural invasion, and extra thyroidal extension (P= 0.002), (P= 0.01) and (P= 0.001) respectively. Conclusions: SIX1 expression is significantly associated with poor prognostic factors and thus can be used as a prognostic indicator for PTC patients. Key words: SIX1, PTC, Immunohistochemistry. | ||||
| Keywords | ||||
| SIX1; PTC; Immunohistochemistry | ||||
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