Evaluation of the therapeutic efficacy of metformin with or without albendazole on experimental muscular trichinosis
Sharaf-El-Deen, S., El-Sobky, M., Sadek, G., El- Aswad, B., Atallah, A., Yassien, R., Ammar, A. (2023). Evaluation of the therapeutic efficacy of metformin with or without albendazole on experimental muscular trichinosis. EKB Journal Management System, 16(3), 246-252. doi: 10.21608/puj.2023.236678.1222
Shaimaa Sharaf-El-Deen; Mona El-Sobky; Gehan Sadek; Bahaa El- Aswad; Amira Atallah; Rania Yassien; Amany Ammar. "Evaluation of the therapeutic efficacy of metformin with or without albendazole on experimental muscular trichinosis". EKB Journal Management System, 16, 3, 2023, 246-252. doi: 10.21608/puj.2023.236678.1222
Sharaf-El-Deen, S., El-Sobky, M., Sadek, G., El- Aswad, B., Atallah, A., Yassien, R., Ammar, A. (2023). 'Evaluation of the therapeutic efficacy of metformin with or without albendazole on experimental muscular trichinosis', EKB Journal Management System, 16(3), pp. 246-252. doi: 10.21608/puj.2023.236678.1222
Sharaf-El-Deen, S., El-Sobky, M., Sadek, G., El- Aswad, B., Atallah, A., Yassien, R., Ammar, A. Evaluation of the therapeutic efficacy of metformin with or without albendazole on experimental muscular trichinosis. EKB Journal Management System, 2023; 16(3): 246-252. doi: 10.21608/puj.2023.236678.1222

Evaluation of the therapeutic efficacy of metformin with or without albendazole on experimental muscular trichinosis

Parasitologists United Journal
Article 10, Volume 16, Issue 3, December 2023, Page 246-252  XML PDF (515.4 K)
Document Type: Original Article
DOI: 10.21608/puj.2023.236678.1222
View on SCiNiTO View on SCiNiTO
Authors
Shaimaa Sharaf-El-Deen email orcid 1; Mona El-Sobky2; Gehan Sadek3; Bahaa El- Aswad2; Amira Atallah2; Rania Yassien4; Amany Ammar5
1Departments of Medical Parasitology, Faculty of Medicine, MenoufiaUniversity,Egypt
2Departments of Medical Parasitology, Faculty of Medicine, Menoufia University
3Departments of Medical Parasitology Faculty of Medicine, Menoufia University,Egypt, and King Salman International University, KSA
4Departments of Histopathology , Faculty of Medicine, Menoufia University
5Departments of Medical Parasitology , Faculty of Medicine, Menoufia University
Abstract
Background: Most drugs used for the treatment of trichinosis showed a limited bioavailability, and
induced adverse side effects on administrating high doses. Therefore, there is a need to develop new
agents to improve the bioavailability of these drugs.
Objective: To assess the efficacy of metformin (MTF) administration as a co-drug with ALZ to treat
muscular trichinosis.
Material and Methods: A total of 25 mice were divided into five equal groups, categorized as negative
control group, and four T. spiralis-infected groups: positive control, MTF-treated group, ALZ-treated group,
and combined MTF-ALZ-treated group. Larval burden, muscle histopathology, new vascular formation by
measuring CD34, and expression of the gene encoding myogenin (Myog) by real time PCR were investigated
at the end of the experiment 35th day post-infection (dpi).
Results: The results demonstrated that the group treated with MTF plus ALZ had the best outcome
among all parameters, followed by the group treated with MTF, and finally the group treated with ALZ.
Both MTF with ALZ proved to be a promising combination for the treatment of muscular trichinosis in
experimentally-infected mice.
Conclusion: It was concluded that MTF reduced the pathology of muscular phase of trichinosis. Further
studies are recommended to better understand MTF pharmacokinetics.
Keywords
albendazole; metformin; muscular vasculature; myogenin; nurse cells; trichinosis
Statistics
Article View: 55
PDF Download: 321