Preoperative topical testosterone for penile hypospadias repair `a comparative study` | ||||
| Annals of Pediatric Surgery | ||||
| Volume 16, Issue 1, January 2020 PDF (8.02 MB) | ||||
| DOI: 10.1186/s43159-020-00050-y | ||||
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| Authors | ||||
Islam Mahmoud Wali; Amr Abdelhamid AbouZeid   ; Nehal Ahmed Radwan; Mohamed Abdel Sattar GadAllah; Wael Ahmed Ghanem; Osama El-Naggar
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| Abstract | ||||
| Background Although the outcome of hypospadias repair has much improved, repair of a small-sized phallus is still challenging. Whether preoperative hormonal therapy is beneficial remains controversial. Results The study included 40 cases of primary hypospadias with a small glans. Their age ranged from 6 months to 3 years. Patients were divided into two equal groups. Group A were treated by local application of testosterone topical gel 1% for 30–40 days and stopped one month before operation, while cases in group B did not receive preoperative hormonal treatment. Genital skin biopsies were taken for histopathological examination. For group A, penile measurements were documented before and after hormonal therapy. Conclusion The use of preoperative topical testosterone significantly increases the size of the hypospadiac phallus. However, this increase in size appears to be disproportionate on the ventral penile surface and has not been reflected on improving the surgical outcome. Level of evidence This is a case control study (level III evidence). | ||||
| Keywords | ||||
| Chordee; Outcome; Hormone; tubularized incised plate; histology | ||||
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