A comparison of nutritional status in patients with neuroblastoma in Rwanda and United Kingdom: a cross-sectional observational study conducted by the OxPLORE collaboration | ||||
| Annals of Pediatric Surgery | ||||
| Volume 18, Issue 1, January 2022 PDF (939.86 K) | ||||
| DOI: 10.1186/s43159-022-00176-1 | ||||
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| Authors | ||||
Emery Manirambona ; Shannon Gunawardana; Hugh Hathaway; Kokila Lakhoo; Kathryn Ford; Aimable Kanyamuhunga 
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| Abstract | ||||
| Background Cancer is a major global health concern and a leading cause of death in paediatric populations worldwide. Malnutrition contributes to a poor prognosis and remains the most common comorbidity leading to death in children with cancer. This retrospective study was developed through Oxford Paediatrics Linking Oncology Research with Electives (OxPLORE)—a medical student-led collaboration of paediatric surgeons and oncologists from low- and middle-income (LMIC) and high-income (HIC) countries. The aim of this study was twofold; firstly, to investigate the nutritional status and outcomes of neuroblastoma paediatric patients in two OxPLORE centres. Secondly, to facilitate the development of research skills of medical students as part of the OxPLORE initiative. Results Nine neuroblastoma patients were identified (YY, = 4, XX, = 5) over the study period. Nutritional status was poorer in YY patients (median -score − 1.57 cf. − 0.7, = 1.16, = 0.28), which correlated with poorer survival in the YY cohort (75%), as compared to the XX cohort (100%). YY patients were older at presentation than the XX cohort (57 cf. 13 months, = 1.959 = 0.09). Further, tumour presentation was at a later stage in the YY group (75% stage IV). Conclusion This collaboration has shown a correlation in disparities in nutritional status and outcome of neuroblastoma in paediatric populations in YY and XX. These findings can inform institutional quality improvement. Further, this pilot study has highlighted the potential for medical students to undertake international research collaborations. | ||||
| Keywords | ||||
| neuroblastoma; Nutritional Status; United Kingdom; Rwanda; Medical students; Research Collaboration | ||||
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