Agents that can be used in medical treatment of meconium ileus and comparison of their efficacy | ||||
| Annals of Pediatric Surgery | ||||
| Volume 18, Issue 1, January 2022 PDF (863.21 K) | ||||
| DOI: 10.1186/s43159-022-00190-3 | ||||
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| Author | ||||
| Krasimir D. Ivanov | ||||
| Abstract | ||||
| Background Aim: This study was conducted to determine the efficacy of medical agents currently used or potentially used in the medical treatment of meconium ileus and to contribute to the medical treatment of meconium ileus. Materials and method In our study, meconium causing meconium ileus or normal meconium obtained voluntarily from healthy newborns at birth was used. A total of 2 g meconium sample was placed in each test tube. Six experimental groups were formed by adding saline solution, N-acetylcysteine, amidotrizoate, pancreatic enzymes, fibrinolytic enzyme, and probiotic bacteria on the meconium samples. All experimental groups were kept at 36 °C and over 90% humidity for 6 h. The resulting mixtures were centrifuged at 2500 rpm for 5 min. Results It was determined that the solid part weights of N-acetylcysteine and amidotrizoate groups increased, while the solid part weights of the other groups decreased. It was determined that the decrease in solid part weights was mostly in the probiotic bacteria group. Test correlation between liquid fraction volume and solid weight was statistically determined. The group that moved the most on the glass substrate was the N-acetylcysteine group. Conclusions Our study also showed that the gastrographin and NAC groups do indeed attract liquid to solid meconium. They cause an increase in solid part weight. Probiotic bacteria and pancreatic enzymes were found effective in terms of movement on the glass surface in the meconium samples they were applied to. The fibrinolytic enzyme produced for in vivo environment was found to be ineffective in the in vitro environment in our study. | ||||
| Keywords | ||||
| Meconium ileus; Medical treatment of meconium; N-acetylcysteine; Amidotrizoate; pancreatic enzymes; Fibrinolytic enzymes; probiotic bacteria | ||||
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