IN VITRO AND IN SILICO APPROACHES FOR SCREENING INTESTINAL PERMEABILITY AND ABSORPTION OF DRUGS.
Elgendy, A., Adejare, A., Abd El-Rasoul, S., Asiri, A. (2024). IN VITRO AND IN SILICO APPROACHES FOR SCREENING INTESTINAL PERMEABILITY AND ABSORPTION OF DRUGS.. EKB Journal Management System, 47(1), 101-117. doi: 10.21608/bfsa.2024.257301.1988
Ahmed Elgendy; Adeboye Adejare; Saleh Abd El-Rasoul; Abdullah Asiri. "IN VITRO AND IN SILICO APPROACHES FOR SCREENING INTESTINAL PERMEABILITY AND ABSORPTION OF DRUGS.". EKB Journal Management System, 47, 1, 2024, 101-117. doi: 10.21608/bfsa.2024.257301.1988
Elgendy, A., Adejare, A., Abd El-Rasoul, S., Asiri, A. (2024). 'IN VITRO AND IN SILICO APPROACHES FOR SCREENING INTESTINAL PERMEABILITY AND ABSORPTION OF DRUGS.', EKB Journal Management System, 47(1), pp. 101-117. doi: 10.21608/bfsa.2024.257301.1988
Elgendy, A., Adejare, A., Abd El-Rasoul, S., Asiri, A. IN VITRO AND IN SILICO APPROACHES FOR SCREENING INTESTINAL PERMEABILITY AND ABSORPTION OF DRUGS.. EKB Journal Management System, 2024; 47(1): 101-117. doi: 10.21608/bfsa.2024.257301.1988

IN VITRO AND IN SILICO APPROACHES FOR SCREENING INTESTINAL PERMEABILITY AND ABSORPTION OF DRUGS.

Bulletin of Pharmaceutical Sciences Assiut University
Article 6, Volume 47, Issue 1, June 2024, Page 101-117  XML PDF (862.8 K)
Document Type: Review Article
DOI: 10.21608/bfsa.2024.257301.1988
View on SCiNiTO View on SCiNiTO
Authors
Ahmed Elgendy email 1, 2, 3; Adeboye Adejare2; Saleh Abd El-Rasoul1, 4; Abdullah Asiri1
1Department of Pharmaceutics, Faculty of Pharmacy, Al-Baha University, Al-Baha, Saudi Arabia
2Department of Pharmaceutical Sciences, Philadelphia College of Pharmacy, Saint Joseph's University, Philadelphia, Pennsylvania, 19131, USA
3Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt
4Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt
Abstract
Because the oral route of drug delivery is incomparable, screening of intestinal permeability and absorption of drug candidates is a critical stage before clinical trials for time and cost reasons. Permeability assessment of drugs after oral administration have been investigated using different in-vitro approaches. Fast, reliable, and non-invasive in-vitro techniques are crucial in the early stages of the drug discovery process as primary screening tools to assess intestinal permeability of lead compounds. In-vitro techniques are either experimental based or computer assisted (in-silico) methods. Experimental methods to predict intestinal permeability of drugs are mainly partitioning based physicochemical models and direct measurement based models that depend on using laborious techniques of isolated human/animal cells or tissues. In this work, partitioning based physicochemical models that can predict a compound/drug permeability potential across intestinal membrane will be elaborated. In addition, in silico models that could be of value in scaling up feasible hit compounds and throwing away possible losers will also be overviewed.
Keywords
Intestinal permeability screening; In vitro approaches; In silico models
Statistics
Article View: 167
PDF Download: 87