Primary Open-angle Glaucoma and Normal Tension Glaucoma Diagnosis: The Role of Macular Thickness Asymmetry
El Sayed, A., Mansour, M. (2023). Primary Open-angle Glaucoma and Normal Tension Glaucoma Diagnosis: The Role of Macular Thickness Asymmetry. EKB Journal Management System, 5(12), 3906-3913. doi: 10.21608/ijma.2023.233510.1797
Ahmed Abd El Aziz El Sayed; Mona N. Mansour. "Primary Open-angle Glaucoma and Normal Tension Glaucoma Diagnosis: The Role of Macular Thickness Asymmetry". EKB Journal Management System, 5, 12, 2023, 3906-3913. doi: 10.21608/ijma.2023.233510.1797
El Sayed, A., Mansour, M. (2023). 'Primary Open-angle Glaucoma and Normal Tension Glaucoma Diagnosis: The Role of Macular Thickness Asymmetry', EKB Journal Management System, 5(12), pp. 3906-3913. doi: 10.21608/ijma.2023.233510.1797
El Sayed, A., Mansour, M. Primary Open-angle Glaucoma and Normal Tension Glaucoma Diagnosis: The Role of Macular Thickness Asymmetry. EKB Journal Management System, 2023; 5(12): 3906-3913. doi: 10.21608/ijma.2023.233510.1797

Primary Open-angle Glaucoma and Normal Tension Glaucoma Diagnosis: The Role of Macular Thickness Asymmetry

International Journal of Medical Arts
Volume 5, Issue 12, December 2023, Page 3906-3913  XML PDF (986.5 K)
Document Type: Original Article
DOI: 10.21608/ijma.2023.233510.1797
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Authors
Ahmed Abd El Aziz El Sayed email orcid 1; Mona N. Mansour2
1Department of Ophthalmology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt
2Department of Ophthalmology, Faculty of Medicine [for girls], Al-Azhar University, Cairo, Egypt
Abstract
Background: According to reports, the macula provides a number of potential physiological and anatomical benefits for glaucoma detection and management.
The Aim of the work: This study aims to determine if spectral domain optical coherence tomography [SD-OCT] measures of macular and peripapillary retinal nerve fiber layer [RNFL] thickness can reliably differentiate between primary open-angle glaucoma [POAG] and normal-tension glaucoma [NTG].
Patients and Methods: A prospective study enrolled 10 healthy participants, 29 glaucomatous patients: 13 with POAG and 16 with NTG. Diagnosis based on intraocular pressures, visual fields, and optic nerves. The following parameters were measured by SD-OCT B-scans: RNFL thickness [circumpapillary scan] and macular thickness [posterior pole asymmetry scan] in both eyes and then recorded in addition to the calculated inter-eye and intra-eye differences [asymmetry parameters]. Receiver operator characteristic [ROC] analysis was used to determine the optimum cut off value for the studied diagnostic markers [RNFL and macular thickness].
Results: Inferior macular thickness asymmetry [intereye] had the highest discrimination for normal-POAG [AUC=0.838, sensitivity = 61.5% at 80% specificity], followed by inferior RNFL thickness [intereye] asymmetry [AUC=0.808, sensitivity = 61.5% at 80% specificity]. For normal-NTG total macular thickness asymmetry [intereye] had the highest discrimination [AUC=0.756, sensitivity = 68.8 % at 80% specificity], followed by inferior RNFL thickness [intereye] asymmetry [AUC=0.700, sensitivity = 62.5 % at 80% specificity].
Conclusion: For the discriminating of NTG and POAG, the macular parameters function is comparable to the RNFL parameters. The top SD-OCT metrics with the best discriminating skills were intereye Inferior macular thickness asymmetry, the total retinal nerve fibre layer thickness, the intereye inferior retinal nerve fibre thickness, and the inferior macular thickness
Keywords
Primary Open-angle Glaucoma; Normal Tension Glaucoma; SD-OCT; RNFL
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