SOME STUDIES ON THE EFFICACY OF TRIQUIN ON TRYPANOSOMA EVANS! | ||||
| Egyptian Journal of Agricultural Research | ||||
| Article 32, Volume 77, Issue 2, March 1999, Page 931-940 PDF (3.15 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejar.1999.336275 | ||||
 View on SCiNiTO | ||||
| Author | ||||
| AHMED A. WAHBA | ||||
| Animal Health Research Institute, Agricultural Research Centre, Giza, Egypt | ||||
| Abstract | ||||
| Two experiments were carried out on 48 experimentally infected rats with Trypanosome evansi. Each experiment included 24 rats. In the first experiment, 16 rats were divided into 4 subgroups each of 4 according to time of examination. Each rat was injected with triquin subcutaneously at a single dose of 4.16 mg/kg body weight. Eight rats were left as untreated control. Fresh blood samples, Giemsa stained blood films, impression smears from different tissues were obtained at 6, 9, 12 and 24 hours post-treatment and examined microscopically. In case of the second experiment, the rats were divided ihto 3 groups each of 8. The first group was supplied with 25% glucose solution orally, while, in the second group, each rat was injected with 2.5 ml of 25% glucose solution intra-peritoneally daily for 3 successive days. The third group was left as untreated control. Giemsa stained blood films from rats were examined one day post-administration of glucose, and then, weekly. Detection, as well as, morphological changes of trypanosomes in the 2 experiments were studied. Some morphological changes of trypanosomes in experimentally infected rats with T.evansi after being supplied with glucose solution only (either orally or i/P), were• nearly similar to those occurring in trypanosomes in rats treated with triquin. The morphological changes included deformity, structural swelling of the poterior part with thinness of the anterior end, ill-defined cell-wall, lightly stained cytoplasm, damage of cytoplasmic membrane, disappearance of flagellum and undulating membrane and degrenerative changes of nucleus. The kinetoplast disappeared or still be found with a vacuole behind it. | ||||
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