Role of Gene Polymorphism of Intercellular Adhesion Molecule 1 (ICAM 1) in Rheumatoid Arthritis | ||||
| Zagazig University Medical Journal | ||||
| Articles in Press, Accepted Manuscript, Available Online from 14 January 2024 | ||||
| Document Type: Review Articles | ||||
| DOI: 10.21608/zumj.2024.252699.3031 | ||||
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| Authors | ||||
Rana Moustafa Magdy Nasr  1; Mona Ahmed Mohamed Shalaby2; Mohamed Ahmed Moselhy Sakr3; Noura E Esmaeel2
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| 1Medical Microbiology and Immunology Department, Faculty of Medicine, Suez University, Egypt | ||||
| 2Medical Microbiology and Immunology Department, Faculty of Medicine, Zagazig University, Egypt | ||||
| 3Medical Microbiology and Immunology department, Faculty of Medicine, Suez University, Suez, Egypt | ||||
| Abstract | ||||
| Joint and extra-articular inflammation are hallmarks of rheumatoid arthritis (RA) that is a systemic autoimmune disease. This condition is long-lasting and mostly affects the synovial joints. Untreated, it spreads from its initial presentation in minor peripheral joints to larger proximal joints. Cartilage and bone deterioration occur as a result of chronic inflammation in a joint. Early RA is diagnosed when symptoms have been present for less than six months, while established RA is diagnosed when symptoms have been present for more than six months. A transmembrane protein belonging to the immunoglobulin superfamily, intercellular adhesion molecule 1 (ICAM-1) is expressed on the surface of several cell types and is stimulated by inflammatory stimuli. By binding to the two integrins, leukocyte function-associated antigen 1 and macrophage antigen 1, as well as other ligands, it mediates cellular sticky connections. Numerous of these molecules are crucial to the rheumatoid arthritis disease process. ICAM-1 gene polymorphism and rheumatoid arthritis clinical activity are related, and a variety of drugs can be used to treat RA by reducing ICAM-1 expression. | ||||
| Keywords | ||||
| Intercellular adhesion molecule 1; rheumatoid arthritis; polymorphism | ||||
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