Evaluation of Minichromosome Maintenance Deficient-5 Levels in non-Muscle invasive Bladder Cancer Patients | ||||
| Egyptian Journal of Chemistry | ||||
| Volume 67, Issue 7, July 2024, Page 581-588 PDF (1.32 MB) | ||||
| Document Type: Review Articles | ||||
| DOI: 10.21608/ejchem.2024.247314.8834 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Faten Zahran Mohamed 1; Reda Abdelaal2; Ehab Elbadry  3; Waleed Mohamed Serag4
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| 1Biochemistry Department, Faculty of Science, Zagazig University | ||||
| 2Professor of organic chemistry Chemistry Department, Faculty of Science, Suez University, Suez – Egypt | ||||
| 3Clinical pathology dept/ damietta cancer institute, Damietta-Egypt. | ||||
| 4Associate Professor of biochemistry Chemistry Department, Faculty of Science, Suez University, Suez – Egypt | ||||
| Abstract | ||||
| Abstract Objectives: The diagnosis of bladder carcinoma is currently made using cytology and cystoscopy, which pose a significant challenge for clinicians due to a lack of sensitivity and specificity; therefore, we examine how well Minichromosome Maintenance Deficient-5 factor (MCM-5) in various body fluids (serum, urine, and tissue homogenate) can detect non muscle invasive bladder cancer (NMIBC) patients. Patients: At Damietta Cancer Institute, Damietta, Egypt, Fifty patients and thirty healthy subjects were recruited and patients pathologically diagnosed as non-muscle invasive bladder cancer. All subjects had their serum, urine, and tissue homogenate marker levels determined. Results: The levels of Minichromosome Maintenance Deficient-5 factor were significantly higher in urine and tissue homogenate samples from Ta and T1 non muscle invasive bladder cancer (NMIBC) patients compared to the control group (p< 0.001), and serum MCM5 levels were significantly higher compared to the control group (P =0.036). Urine MCM-5 had a higher negative predictive value (NPV) and positive predictive value (PPV) than the other fluids (serum and tissue homogenate) and could be used as a predictive marker for the recurrence of NMIBC. Conclusions: The urinary Minichromosome Maintenance Deficient-5 assay is a simple and inexpensive test that may be useful as a biomarker for the diagnosis of non-muscle invasive bladder cancer patients and to determine patients who need to have their cystoscopy repeated. | ||||
| Keywords | ||||
| Bladder cancer; MCM5; NMIBC; NPV; PPV | ||||
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