The Association Between Ki-67 Proliferation Index and Disease Progression in Gastro Intestinal Stromal Tumors: A Retrospective Study | ||||
| SECI Oncology Journal | ||||
| Volume 12, Issue 1, January 2024, Page 1-13 | ||||
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| Abstract | ||||
| Introduction: Approximately 40% to 50% of high risk Gastro intestinal stromal tumors progress even with complete surgical resection. Therefore, prognostication of patients is essential to determine the risk of recurrence and influence management decisions. Many risk stratification systems have developed. Tumor size, site and mitotic count are the major clinicopathologic risk factors together with tumor rupture. The nuclear proliferating protein ki-67 has demonstrated its prognostic significance in the outcome of various malignancies but in gastro intestinal stromal tumors, the relationship between its overexpression and the risk of disease recurrence remains poorly defined. Aim of the work: To investigate whether Ki-67 labelling index can be considered an independent predictor for disease progression or not. Patients and methods: This is a retrospective study that enrolled patients with localized stage of gastrointestinal stromal tumors treated by surgical excision and adjuvant Imatinib mesylate in the Governorate of Sohag between January 2012 and January 2022. Results: A total of 74 Egyptian patients with localized gastrointestinal stromal tumors treated with excision and adjuvant Imatinib mesylate have been retrospectively analyzed. The median age was 53 year and the median follow up period was at 40 months. During follow up, 27% has developed progressions both local and distant and 12% has died. Among the studied risk factors, only the extra gastric location and Ki-67% labelling index >7% were associated with more disease recurrences in univariate analysis. A labelling index ≤7% was associated with better local and distant control in the studied subgroups but with no effect on overall survival. Conclusion: Ki-67% labelling index >7% is an important prognostic indicator of high risk of disease progression after surgical excision of localized GIST and more larger studies are warranted. | ||||
| Keywords | ||||
| Ki-67 proliferation index; disease progression; GIST | ||||
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