Evaluation of the efficacy of camel milk lactoferrin nanoliposome against colorectal cancer
Hendy, S., Gamal El Din, A., Abdel Fatah, E., Salama, W., Mostafa, H., Azab, R., Yacoub, S. (2023). Evaluation of the efficacy of camel milk lactoferrin nanoliposome against colorectal cancer. EKB Journal Management System, 1(2), 43-55. doi: 10.21608/jpfs.2024.259780.1005
Sameh Abdallah Hendy; A. H. Gamal El Din; Ezzat Ahmed Abdel Fatah; Wafaa M. Salama; Hosam El-Din Mostafa; Rania M. Azab; Sameh S. Yacoub. "Evaluation of the efficacy of camel milk lactoferrin nanoliposome against colorectal cancer". EKB Journal Management System, 1, 2, 2023, 43-55. doi: 10.21608/jpfs.2024.259780.1005
Hendy, S., Gamal El Din, A., Abdel Fatah, E., Salama, W., Mostafa, H., Azab, R., Yacoub, S. (2023). 'Evaluation of the efficacy of camel milk lactoferrin nanoliposome against colorectal cancer', EKB Journal Management System, 1(2), pp. 43-55. doi: 10.21608/jpfs.2024.259780.1005
Hendy, S., Gamal El Din, A., Abdel Fatah, E., Salama, W., Mostafa, H., Azab, R., Yacoub, S. Evaluation of the efficacy of camel milk lactoferrin nanoliposome against colorectal cancer. EKB Journal Management System, 2023; 1(2): 43-55. doi: 10.21608/jpfs.2024.259780.1005

Evaluation of the efficacy of camel milk lactoferrin nanoliposome against colorectal cancer

Journal of Plant and Food Sciences
Volume 1, Issue 2, December 2023, Page 43-55  XML PDF (664.53 K)
Document Type: Original Article
DOI: 10.21608/jpfs.2024.259780.1005
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Authors
Sameh Abdallah Hendy email orcid 1; A. H. Gamal El Din2; Ezzat Ahmed Abdel Fatah2; Wafaa M. Salama3; Hosam El-Din Mostafa4; Rania M. Azab4; Sameh S. Yacoub5
1Dairy Science Department, Faculty of Agriculture, Al-Azhar University, Cairo, Egypt.gypt
2Dairy Science Department, Faculty of Agriculture, Al-Azhar University, Cairo, Egypt.
3Dairy Res. Dept., Food Technology Research Institute, Agriculture Research Center, Giza, Egypt.
4National Institute of Laser Enhanced Sciences (NILES). Cairo University, Giza, Egypt.
5Faculty of Agriculture, Damanhour University, Damanhour, Egypt.
Abstract
Colorectal cancer (CRC) is a significant cause of death and cancer-related mortality worldwide. Lactoferrin (LF) is a promising molecule that was found to inhibit the growth of cancerous tumor.  This study explores the effect of camel milk lactoferrin nanoliposome (LFnl) on colorectal cancer (HTC-116 cells) as a potential therapeutic agent against colorectal cancer. The total purified camel milk LF concentration was 200 mg/l. Film hydration technique was used to produce LFnl. Advanced characterization revealed distinct nanoliposome shapes with a clear two-layered structure. The particle size ranged between 28.3 – 139 nm, and the zeta potential value was -22.6 mV. Exceptional encapsulation efficiency of 99.32% was achieved. The examination of HTC-116 cells and normal cells WI-38 elucidated an IC50 value of 40.5±0.9 µg/ml. while, the cytotoxicity assessments conducted on WI-38 cells exhibited a CC50 value of 43.5±0.3 µg/ml. This result indicated that LFnl should be used carefully when treated colorectal cancer.
Keywords
Camel Milk; Lactoferrin; Nanoliposome; Colorectal Cancer
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