Synthesis and Characterization of Novel Phthalazin-1(2H)-one Hybrids with Anticipated Antibacterial Activity | ||||
| Egyptian Journal of Chemistry | ||||
| Volume 67, Issue 8, August 2024, Page 351-366 PDF (536.07 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2024.258130.9071 | ||||
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| Authors | ||||
Asmaa Kamal Mourad   1; Ahmed Yousef Soliman2; Abdelmoneim Abdelsalam Makhlouf3; Fatehia Korany Mohammed1; Samar Ahmed Mohamed1
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| 1Department of Chemistry, Faculty of Science, Fayoum University, Fayoum-Egypt | ||||
| 2Department of Chemistry, Faculty of Science, Fayoum University,Fayoum-Egypt | ||||
| 3Department of chemistry, Faculty of Science, Fayoum University, Fayoum-Egypt | ||||
| Abstract | ||||
| Herein, a phthalazine acetohydrazide derivative 4 was assembled and its behaviour towards carbon nucleophiles was thoroughly investigated. Subsequently, phthalazine derivative 4 was used as a valuable scaffold for synthesizing assorted heterocycles such as pyrazol, thiazolidine, and azetidine. Diversified reaction conditions and reagents were explored. The assigned structures of the assembled heterocycles were elucidated utilizing IR, 1H NMR, 13C NMR, MS, and elemental analysis. Finally, the newly assembled heterocycles were evaluated in vitro for their antibacterial activities. | ||||
| Keywords | ||||
| Acetohydrazide; Thiazolidine; 2-Azetidinone; Pyrazole; Antibacterial | ||||
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